Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK5 | O95279 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KCNK17 | Q96T54 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990019 | 0.91 | LMNA (0.57) | PDE10ALMNAPTGER4PLA2G1BATG4B | |
| SCHEMBL30990047 | 0.89 | MET (0.51) | METPDE10ALMNAPTGER4MAOB | |
| SCHEMBL30989996 | 0.84 | MET (0.53) | METPDE10ALMNAPTGER4MAOB | |
| SCHEMBL30989911 | 0.81 | RIPK1 (0.46) | LMNAPTGER4RIPK1PLA2G1BATG4B | |
| SCHEMBL30989879 | 0.80 | LMNA (0.55) | PDE10ALMNAPTGER4RIPK1MAPT | |
| SCHEMBL30989781 | 0.79 | RIPK1 (0.46) | LMNARIPK1MAPTMEN1KMT2A | |
| SCHEMBL922929 | 0.78 | MET (0.53) | METPDE10APLA2G1BATG4BROCK2 | |
| SCHEMBL30989888 | 0.76 | ROCK2 (0.53) | METPDE10APTGER4RIPK1ROCK2 | |
| SCHEMBL30989895 | 0.74 | KCNA5 (0.52) | METPDE10APTGER4RIPK1ROCK2 | |
| SCHEMBL30989915 | 0.74 | LMNA (0.80) | LMNAMAPTMAPK8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |