Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491503 | 0.78 | CYP3A4 (0.53) | ADORA2BDYRK1ATDO2BACE1LOX | |
| SCHEMBL16013957 | 0.78 | ADORA2B (0.46) | ADORA2BDYRK1ATDO2BACE1LOX | |
| SCHEMBL16971558 | 0.78 | ALOX5AP (0.37) | ADORA2BDYRK1ATDO2 | |
| SCHEMBL4279791 | 0.75 | DYRK1A (0.43) | ADORA2BDYRK1ABACE1ADORA2AS1PR1 | |
| SCHEMBL30296351 | 0.75 | TDO2 (0.43) | ADORA2BDYRK1ATDO2BACE1LOX | |
| SCHEMBL24196194 | 0.75 | KIT (0.47) | DYRK1ATDO2BACE1LOXLOXL2 | |
| SCHEMBL31174103 | 0.74 | F11 (0.40) | ADORA2BDYRK1ATDO2GRM2GRM5 | |
| SCHEMBL23063240 | 0.74 | LOX (0.42) | DYRK1ALOXLOXL2ADORA2ACNR1 | |
| SCHEMBL18755256 | 0.73 | LOX (0.45) | ADORA2BDYRK1ABACE1LOXLOXL2 | |
| SCHEMBL30995101 | 0.72 | CNR1 (0.47) | DYRK1ATDO2BACE1LOXLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4737457-A1 | POLYSUBSTITUTED MACROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shenzhen Salubris Pharmaceuticals Co., Ltd. (CN) | 2026-05-06 | — | — | EP | disclosed |
| CN-119894901-A | Polysubstituted macrocyclic compound, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2025002297-A1 | POLYSUBSTITUTED MACROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳信立泰药业股份有限公司 | 2025-01-02 | — | — | WO | disclosed |
| CN-118126046-A | Substituted macrocyclic compound, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-06-04 | — | — | CN | disclosed |