Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668245 | 0.87 | NPC1 (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL21758196 | 0.84 | NPC1 (0.47) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL31077477 | 0.79 | PNMT (0.46) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL1539672 | 0.76 | PNMT (0.46) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL5837265 | 0.75 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL27942181 | 0.75 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL7877087 | 0.75 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL2043313 | 0.75 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL2938536 | 0.74 | RAB9A (0.47) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL31229252 | 0.74 | HSP90AA1 (0.67) | NPC1RAB9AHTR2BHTR7PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615441-A1 | COMPOUNDS AND COMPOSITIONS AS EIF4E INHIBITORS AND USES THEREOF | Ribometrix, Inc. (US) | 2025-09-17 | — | — | EP | disclosed |
| US-20240246918-A1 | COMPOUNDS AND COMPOSITIONS AS EIF4E INHIBITORS AND THE USES THEREOF | RIBOMETRIX, INC. | 2024-07-25 | — | — | US | disclosed |
| WO-2024103067-A1 | COMPOUNDS AND COMPOSITIONS AS eIF4E INHIBITORS AND USES THEREOF | RIBOMETRIX, INC. (US) | 2024-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246918-A1 | COMPOUNDS AND COMPOSITIONS AS EIF4E INHIBITORS AND THE USES THEREOF | EIF4E, EIF4EBP1, EIF4A1 | NPC1 1653/4885RAB9A 956/4885HTR2B 4446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.