Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668245 | 0.84 | NPC1 (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL30996992 | 0.84 | NPC1 (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL1539672 | 0.77 | PNMT (0.46) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL8971039 | 0.77 | PNMT (0.46) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL2938536 | 0.75 | RAB9A (0.47) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL2687014 | 0.74 | PNMT (0.44) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL7877087 | 0.73 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL5837265 | 0.73 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL2043313 | 0.73 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT | |
| SCHEMBL27942181 | 0.73 | PNMT (0.49) | NPC1RAB9AHTR2BHTR7PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11884619-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2024-01-30 | — | — | US | disclosed |
| US-20220055979-A1 | Reagents and Methods for Esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2022-02-24 | — | — | US | disclosed |
| US-11091423-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2021-08-17 | — | — | US | disclosed |
| US-20200190011-A1 | Reagents and Methods for Esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2020-06-18 | — | — | US | disclosed |
| US-10577303-B1 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2020-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190011-A1 | Reagents and Methods for Esterification | ADCY1, ADCY4, ADCY7 | NPC1 3038/4885RAB9A 1875/4885HTR2B 2398/4885 |
| US-11091423-B2 | Reagents and methods for esterification | ADCY1, ADCY4, ADCY7 | NPC1 3038/4885RAB9A 1875/4885HTR2B 2398/4885 |
| US-10577303-B1 | Reagents and methods for esterification | ADCY1, ADCY4, ADCY7 | NPC1 3038/4885RAB9A 1875/4885HTR2B 2398/4885 |
| US-11884619-B2 | Reagents and methods for esterification | ADCY1, ADCY4, ADCY7 | NPC1 3038/4885RAB9A 1875/4885HTR2B 2398/4885 |
| US-20220055979-A1 | Reagents and Methods for Esterification | ADCY1, ADCY4, ADCY7 | NPC1 3038/4885RAB9A 1875/4885HTR2B 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.