Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | PTPRCAP | Q14761 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689417 | 0.88 | DRD1 (0.65) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL9976810 | 0.87 | DRD2 (0.63) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL5325477 | 0.85 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL11055620 | 0.84 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL29398835 | 0.84 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL27850407 | 0.84 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL29390321 | 0.83 | KDM4E (0.84) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| Actinodaphnine SCHEMBL29596257 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| Actinodaphnine SCHEMBL674832 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| Actinodaphnine SCHEMBL30477775 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118703454-A | Cytochrome P450 enzyme from stephania tetrandra and application thereof in biosynthesis of aporphine alkaloid compound | 中国中医科学院中药研究所 | 2024-09-27 | — | — | CN | claimed |
| CN-118703454-A | Cytochrome P450 enzyme from stephania tetrandra and application thereof in biosynthesis of aporphine alkaloid compound | 中国中医科学院中药研究所 | 2024-09-27 | — | — | CN | disclosed |
| CN-118547022-A | Preparation method of aporphine alkaloid compound and related catalytic enzyme and application thereof | 中国中医科学院中药研究所 | 2024-08-27 | — | — | CN | disclosed |