Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CASP1 | P29466 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CASP7 | P55210 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29398835 | 0.94 | ALDH1A1 (0.69) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11055620 | 0.94 | ALDH1A1 (0.69) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27850407 | 0.94 | ALDH1A1 (0.69) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29039792 | 0.88 | DRD2 (0.81) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31029778 | 0.87 | KDM4E (0.70) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30029891 | 0.86 | HTR2C (0.77) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14259791 | 0.86 | DRD1 (0.71) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29506718 | 0.86 | HTR2C (0.77) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9976807 | 0.86 | DRD1 (0.76) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Laurotetanine SCHEMBL31300083 | 0.83 | DRD2 (0.74) | DRD2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202995-B2 | Pharmaceutically acceptable salts of aporphine derivatives and carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-06-19 | — | — | US | disclosed |
| US-8202995-B2 | Pharmaceutically acceptable salts of aporphine derivatives and carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-06-19 | — | — | US | disclosed |
| US-8093260-B2 | Aporphine derivatives and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-01-10 | — | — | US | disclosed |
| US-8093260-B2 | Aporphine derivatives and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-01-10 | — | — | US | disclosed |
| US-20090318489-A1 | Aporphine compounds and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-20090318488-A1 | Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-20090318488-A1 | Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-20090318489-A1 | Aporphine compounds and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-7294715-B2 | Aporphine and oxoaporphine compounds and pharmaceutical use thereof | LOTUS PHARMACEUTICAL CO., LTD. (TW) | 2007-11-13 | — | — | US | disclosed |
| US-7294715-B2 | Aporphine and oxoaporphine compounds and pharmaceutical use thereof | LOTUS PHARMACEUTICAL CO., LTD. (TW) | 2007-11-13 | — | — | US | disclosed |
| US-4461895-A | FOR COMBATTING COLDS AND ALLERGIES | WARNER-LAMBERT COMPANY (US) | 1984-07-24 | — | — | US | disclosed |
| EP-0064685-A1 | Dibenzo(de,g)quinolines, processes for their preparation and pharmaceutical preparations containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318489-A1 | Aporphine compounds and pharmaceutical use thereof | IAPP, OPRL1, AGER | DRD2 163/4885KDM4E 3212/4885ALDH1A1 849/4885 |
| US-20090318488-A1 | Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same | IAPP, GPR119, AMY2A | DRD2 682/4885KDM4E 3011/4885ALDH1A1 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.