SCHEMBL310330

SCHEMBL310330

COc1cc(F)c(Cl)cc1[N+](=O)[O-]

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
MAPT P10636 2/20 0.45
TDP1 Q9NUW8 2/20 0.44
KDM4E B2RXH2 1/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
PRKDC P78527 1/20 0.44
HSD17B10 Q99714 1/20 0.44
LMNA P02545 2/20 0.43
SLC6A4 P31645 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
TUBB4A P04350 1/20 0.40
TUBB P07437 1/20 0.40
TUBA3C P0DPH7 1/20 0.40
TUBA1B P68363 1/20 0.40
TUBA4A P68366 1/20 0.40
TUBB4B P68371 1/20 0.40
TUBB3 Q13509 1/20 0.40
TUBB2A Q13885 1/20 0.40
TUBB8 Q3ZCM7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25273441 0.93 LMNA (0.47) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL2798396 0.86 ALDH1A1 (0.44) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL30780970 0.86 ALDH1A1 (0.44) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL10983166 0.85 LMNA (0.51) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL517768 0.85 ALDH1A1 (0.50) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL29661436 0.85 ALDH1A1 (0.50) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL11661312 0.84 ALDH1A1 (0.48) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL31757016 0.84 ALDH1A1 (0.51) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL30801468 0.84 ALDH1A1 (0.48) ALDH1A1MAPTTDP1KDM4ECYP3A4
SCHEMBL12458650 0.84 ALDH1A1 (0.48) ALDH1A1MAPTTDP1KDM4ECYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120081802-A Heterocyclic substituted benzamide derivative and application thereof 南华大学附属第一医院 2025-06-03 CN disclosed
US-20250101052-A1 COMPOUND FOR EGFR KINASE INHIBITOR, COMPOSITION, AND USE THEREOF INNOVATION INSTITUTE FOR ARTIFICIAL INTELLIGENCE IN MEDICINE OF ZHEJIANG UNIVERSITY (CN) 2025-03-27 US disclosed
EP-4506343-A1 HETEROARYL DERIVATIVE AND USE THEREOF Voronoi Inc. (KR) 2025-02-12 EP disclosed
US-20240408216-A1 PROTEIN INHIBITOR OR DEGRADING AGENT, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PHARMACEUTICAL USE JING MEDICINE TECHNOLOGY (SHANGHAI) LTD. (CN) 2024-12-12 US disclosed
US-20240383923-A1 HETEROARYL DERIVATIVE AND USE THEREOF VORONOI INC. (KR) 2024-11-21 US disclosed
CN-118946557-A Heteroaryl derivatives and uses thereof 株式会社沃若诺伊 2024-11-12 CN disclosed
EP-4361163-A1 PROTEIN INHIBITOR OR DEGRADING AGENT, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PHARMACEUTICAL USE JING MEDICINE TECHNOLOGY (SHANGHAI) LTD. (CN) 2024-05-01 EP disclosed
US-20240091226-A1 Forms and Formulations Of A Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitor SUMITOMO PHARMA ONCOLOGY, INC. 2024-03-21 US disclosed
CN-117203216-A Protein inhibitor or degradation agent, pharmaceutical composition containing same and medical application 和径医药科技(上海)有限公司 2023-12-08 CN disclosed
US-20230373960-A1 INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS BEONE MEDICINES I GMBH (CH) 2023-11-23 US disclosed
US-20100216779-A1 Imidazopyridine Kinase Inhibitors GLAXOSMITHKLINE LLC 2010-08-26 US disclosed
US-20100216779-A1 Imidazopyridine Kinase Inhibitors GLAXOSMITHKLINE LLC 2010-08-26 US disclosed
WO-2010045451-A1 PYRROLOPYRIMIDINE COMPOUNDS GLAXOSMITHKLINE LLC (US) 2010-04-22 WO disclosed
WO-2010045451-A1 PYRROLOPYRIMIDINE COMPOUNDS GLAXOSMITHKLINE LLC (US) 2010-04-22 WO disclosed
EP-2162454-A1 IMIDAZOPYRIDINE KINASE INHIBITORS GlaxoSmithKline LLC (US) 2010-03-17 EP disclosed
WO-2008150799-A1 IMIDAZOPYRIDINE KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-11 WO disclosed
WO-2008150799-A1 IMIDAZOPYRIDINE KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-11 WO disclosed
US-20080300242-A1 Imidazopyridine Kinase Inhibitors GLAXOSMITHKLINE LLC 2008-12-04 US disclosed
US-20080300242-A1 Imidazopyridine Kinase Inhibitors GLAXOSMITHKLINE LLC 2008-12-04 US disclosed
US-20080300242-A1 Imidazopyridine Kinase Inhibitors GLAXOSMITHKLINE LLC 2008-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230373960-A1 INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS EGFR, ERBB2, ERBB4 ALDH1A1 3986/4885MAPT 2274/4885TDP1 1830/4885
US-20080300242-A1 Imidazopyridine Kinase Inhibitors ABL1, MAP3K19, MAP3K5 ALDH1A1 3410/4885MAPT 2367/4885TDP1 1064/4885
US-20100216779-A1 Imidazopyridine Kinase Inhibitors ABL1, MAP3K19, MAP3K5 ALDH1A1 3410/4885MAPT 2367/4885TDP1 1064/4885
US-20250101052-A1 COMPOUND FOR EGFR KINASE INHIBITOR, COMPOSITION, AND USE THEREOF EGFR, ERBB2, ERBB3 ALDH1A1 2593/4885MAPT 2724/4885TDP1 4147/4885
US-20240408216-A1 PROTEIN INHIBITOR OR DEGRADING AGENT, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PHARMACEUTICAL USE PSME1, IDE, PRUNE1 ALDH1A1 4213/4885MAPT 388/4885TDP1 2032/4885
US-20240091226-A1 Forms and Formulations Of A Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitor TNK1, TNNI3K, TYK2 ALDH1A1 4034/4885MAPT 522/4885TDP1 596/4885
US-20240383923-A1 HETEROARYL DERIVATIVE AND USE THEREOF ERBB2, ERBB3, EGFR ALDH1A1 955/4885MAPT 2826/4885TDP1 4156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.