Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL27668327 | 0.95 | SLC1A2 (0.50) | SLC1A2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL4441158 | 0.85 | SLC1A2 (0.47) | SLC1A2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL12212883 | 0.81 | SLC1A2 (0.69) | SLC1A2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL27668326 | 0.80 | SLC1A2 (0.43) | SLC1A2TSHRMEN1KMT2ASLC1A3 | |
| SCHEMBL9432674 | 0.79 | TSHR (0.42) | SLC1A2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL27740621 | 0.79 | SLC1A2 (0.45) | SLC1A2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL14486583 | 0.79 | — | — | |
| SCHEMBL8846597 | 0.79 | — | — | |
| SCHEMBL7055006 | 0.79 | MEN1 (0.46) | SLC1A2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL7959976 | 0.79 | SLC1A2 (0.42) | SLC1A2TSHRMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172450-B9 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |
| CN-101842473-B | Novel nitrile and amidoxime compounds and methods of preparation | EKC TECHNOLOGY INC | 2013-02-13 | — | — | CN | disclosed |
| CN-101910057-A | Stabilization of hydroxylamine containing solutions and method for their preparation | EKC TECHNOLOGY INC | 2010-12-08 | — | — | CN | disclosed |
| CN-101842473-A | Novel nitrile and amidoxime compounds and methods of preparation | EKC TECHNOLOGY INC | 2010-09-22 | — | — | CN | disclosed |
| US-20100228026-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-09-09 | — | — | US | disclosed |
| EP-2172450-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-04-07 | — | — | EP | disclosed |
| US-20090318290-A1 | N-(4-PYRIDIN-2-YLBUTYL) BENZAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE SA (FR) | 2009-12-24 | — | — | US | disclosed |
| EP-2041090-A1 | N- (4-PYRIDIN-2-YLBUTYL) BENZAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | Bayer CropScience SA (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008003745-A1 | N- (4-PYRIDIN-2-YLBUTYL) BENZAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE SA (FR) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008003746-A1 | N-(4-PYRIDIN-2-YLBUTYL) CARBOXAMIDE DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE SA (FR) | 2008-01-10 | — | — | WO | disclosed |
| EP-0068834-B1 | PYRIMIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-09-03 | — | — | EP | disclosed |
| US-4535163-A | ANTIHISTAMINES; PYRIMIDONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-13 | — | — | US | disclosed |
| US-4444772-A | 2-(3,5-DISUBSTITUTED-PYRIDYLALKYLAMINO)-5-PYRIDYLMETHYL-4 -PYRIMIDONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-24 | — | — | US | disclosed |
| EP-0068834-A2 | Pyrimidinone derivatives and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-01-05 | — | — | EP | disclosed |
| US-4022792-A | ANALGESICS | STERLING DRUG INC. (US) | 1977-05-10 | — | — | US | disclosed |
| US-3976653-A | ANALGESIC ANTAGONIST | STERLING DRUG INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318290-A1 | N-(4-PYRIDIN-2-YLBUTYL) BENZAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | CYP1A2, CYP51A1, CYP4B1 | SLC1A2 2779/4885TSHR 2585/4885MEN1 1450/4885 |
| US-20100228026-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | REN, AGTR2, AGTR1 | SLC1A2 880/4885TSHR 678/4885MEN1 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.