Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12109610 | 0.86 | MAPT (0.57) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL12109613 | 0.83 | MAPT (0.67) | NPC1RAB9AL3MBTL1MAPTTP53 | |
| SCHEMBL13290583 | 0.82 | HPGD (0.53) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL12109603 | 0.81 | RAB9A (0.56) | NPC1RAB9AMAPTGAASMN1; SMN2 | |
| SCHEMBL1247905 | 0.79 | RAB9A (0.63) | NPC1RAB9AL3MBTL1MAPTTP53 | |
| SCHEMBL3101925 | 0.79 | L3MBTL1 (0.83) | NPC1RAB9AL3MBTL1MAPTTP53 | |
| SCHEMBL3170463 | 0.78 | ADORA3 (0.40) | NPC1RAB9AL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL4983521 | 0.77 | TRPV1 (0.65) | NPC1RAB9AL3MBTL1MAPTTP53 | |
| SCHEMBL3156424 | 0.77 | ADORA2A (0.46) | NPC1RAB9AL3MBTL1MAPTTP53 | |
| SCHEMBL3101094 | 0.77 | ROCK2 (0.69) | NPC1RAB9AL3MBTL1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362056-B2 | 4-heteroaryl-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20100273850-A1 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA, INC. | 2010-10-28 | — | — | US | disclosed |
| WO-2009061730-A2 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID | ARRAY BIOPHARMA INC. (US) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273850-A1 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | CD22, HRH2, PTGDR2 | NPC1 2895/4885RAB9A 1817/4885L3MBTL1 2188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.