Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.44 |
| ▸ | GPR4 | P46093 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057641 | 0.90 | GPR4 (0.45) | ACKR3KDM4EALDH1A1SHMT1GPR4 | |
| SCHEMBL31578942 | 0.86 | ACKR3 (0.53) | ACKR3KDM4EALDH1A1GPR4EPHX2 | |
| SCHEMBL31057929 | 0.86 | SHMT1 (0.44) | ACKR3SHMT1GPR4EPHX2GPR119 | |
| SCHEMBL31057939 | 0.79 | SIGMAR1 (0.42) | ACKR3KDM4EALDH1A1SHMT1GPR4 | |
| SCHEMBL31578664 | 0.78 | ACKR3 (0.53) | ACKR3KDM4EALDH1A1EPHX2HPGD | |
| SCHEMBL31578853 | 0.77 | ACKR3 (0.48) | ACKR3ALDH1A1GPR4EPHX2GPR119 | |
| SCHEMBL30983899 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1GPR4EPHX2GPR119 | |
| SCHEMBL30983866 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1GPR4EPHX2GPR119 | |
| SCHEMBL31057911 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1SHMT1SHMT2HPGD | |
| SCHEMBL30696783 | 0.74 | EPHX2 (0.56) | KDM4EALDH1A1GPR4EPHX2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |