Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 7/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 4/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.43 |
| ▸ | GPR4 | P46093 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057641 | 0.93 | GPR4 (0.45) | SHMT1ACKR3GPR4GPR119EPHX2 | |
| SCHEMBL31057975 | 0.92 | SHMT1 (0.42) | SHMT1SHMT2LTA4HSIGMAR1 | |
| SCHEMBL31057873 | 0.89 | SIGMAR1 (0.43) | SHMT1SHMT2ACKR3SIGMAR1 | |
| SCHEMBL31057939 | 0.86 | SIGMAR1 (0.42) | SHMT1SHMT2ACKR3GPR4CYP1A2 | |
| SCHEMBL31057864 | 0.86 | ACKR3 (0.49) | SHMT1SHMT2ACKR3GPR4GPR119 | |
| SCHEMBL31057868 | 0.84 | SIGMAR1 (0.43) | SHMT1ACKR3SIGMAR1 | |
| SCHEMBL31057883 | 0.83 | SIGMAR1 (0.45) | SHMT1ACKR3SIGMAR1 | |
| SCHEMBL31578816 | 0.81 | ACKR3 (0.47) | SHMT1SHMT2ACKR3GPR4GPR119 | |
| SCHEMBL31578853 | 0.80 | ACKR3 (0.48) | ACKR3GPR4GPR119EPHX2HRH2 | |
| SCHEMBL31578739 | 0.80 | ACKR3 (0.51) | SHMT2ACKR3GPR4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |