Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.48 |
| ▸ | GPR4 | P46093 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 10/20 | 0.45 |
| ▸ | HRH1 | P35367 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31578942 | 0.90 | ACKR3 (0.53) | ACKR3GPR4CYP4F2CYP4A11HRH2 | |
| SCHEMBL31057641 | 0.87 | GPR4 (0.45) | ACKR3GPR4CYP4F2CYP4A11HRH2 | |
| SCHEMBL31578793 | 0.85 | ACKR3 (0.48) | ACKR3GPR4CYP4F2CYP4A11HRH2 | |
| SCHEMBL31578739 | 0.83 | ACKR3 (0.51) | ACKR3GPR4ALDH1A1MAPTEPHX2 | |
| SCHEMBL31057929 | 0.80 | SHMT1 (0.44) | ACKR3GPR4CYP4F2CYP4A11HRH2 | |
| SCHEMBL31578727 | 0.80 | ACKR3 (0.51) | ACKR3HRH2HRH1 | |
| SCHEMBL31578678 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPT | |
| SCHEMBL31578816 | 0.79 | ACKR3 (0.47) | ACKR3GPR4CYP4F2HRH2HRH1 | |
| SCHEMBL31057864 | 0.77 | ACKR3 (0.49) | ACKR3GPR4ALDH1A1GPR119EPHX2 | |
| SCHEMBL23643776 | 0.77 | GPR4 (0.44) | GPR4CYP4F2CYP4A11HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163075-A1 | HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2025-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163075-A1 | HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS | KLHDC2, KLHL6, KLHL20 | ACKR3 3274/4885GPR4 4159/4885CYP4F2 2885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.