SCHEMBL31073239

SCHEMBL31073239

CC(C)(C)[Si](C)(C)OCc1ccc(N2CCN(Cc3ccc(N)nc3)CC2)cc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 9/20 0.40
DRD2 P14416 4/20 0.40
DRD3 P35462 4/20 0.40
POLB P06746 1/20 0.37
CHKA P35790 1/20 0.37
MAPT P10636 2/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
GCK P35557 1/20 0.35
GCKR Q14397 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GFER P55789 1/20 0.35
HTR2C P28335 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31073006 0.83 HRH3 (0.38) GCKGCKR
SCHEMBL31073137 0.82 GCK (0.37) MAPTALDH1A1GAAGCKGCKR
SCHEMBL20037567 0.81 HRH3 (0.41) PPARDALDH1A1GAA
SCHEMBL31073086 0.81 TRPC6 (0.36) DRD4DRD2DRD3GCKGCKR
SCHEMBL31073002 0.81 GCK (0.38) GCKGCKR
SCHEMBL31073273 0.80 USP14 (0.33) GCKGCKR
SCHEMBL31073262 0.79 HRH3 (0.36) MAPT
SCHEMBL643187 0.79 GABRP (0.41) KDM4E
SCHEMBL30423197 0.79 GABRP (0.41) KDM4E
SCHEMBL31073352 0.79 TRPC6 (0.39) GCKGCKR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024173646-A1 CYCLIN-DEPENDENT KINASE DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-08-22 WO disclosed