Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19640303 | 0.94 | TSHR (0.52) | GMNNALDH1A1LMNATP53TSHR | |
| Potassium Ion SCHEMBL32680151 | 0.92 | TSHR (0.44) | GMNNALDH1A1LMNATP53TSHR | |
| SCHEMBL1009169 | 0.86 | TSHR (0.50) | GMNNALDH1A1LMNATP53TSHR | |
| SCHEMBL6730611 | 0.84 | TSHR (0.45) | GMNNALDH1A1LMNATP53TSHR | |
| SCHEMBL8532301 | 0.84 | TSHR (0.43) | GMNNALDH1A1LMNATP53TSHR | |
| SCHEMBL8529764 | 0.82 | MEN1 (0.46) | GMNNALDH1A1LMNATP53TSHR | |
| SCHEMBL716072 | 0.80 | TSHR (0.44) | GMNNALDH1A1LMNATP53TSHR | |
| Potassium Ion SCHEMBL28991812 | 0.80 | GMNN (0.40) | GMNNALDH1A1LMNATP53TSHR | |
| Potassium Ion SCHEMBL28692619 | 0.79 | GMNN (0.42) | GMNNALDH1A1LMNATP53TSHR | |
| Potassium Ion SCHEMBL28472448 | 0.78 | ALDH1A1 (0.58) | GMNNALDH1A1LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279713-A1 | DEGENERATE OLIGONUCLEOTIDES AND THEIR USES | SIGMA ALDRICH CO LLC (US) | 2024-08-22 | — | — | US | disclosed |