Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3115063 | 0.84 | ADORA2A (0.47) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL13247850 | 0.84 | ADORA1 (0.45) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL3105542 | 0.80 | ADORA1 (0.49) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL835139 | 0.78 | ADORA1 (0.44) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL13247876 | 0.77 | PGR (0.50) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL3115458 | 0.77 | ADORA2A (0.47) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL835725 | 0.77 | ADORA2B (0.50) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL13247888 | 0.76 | RAB9A (0.48) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL3123850 | 0.76 | ADORA1 (0.49) | ADORA1ADORA2AADORA2BKDM4EMEN1 | |
| SCHEMBL3115718 | 0.76 | ADORA2A (0.55) | ADORA1ADORA2AADORA2BKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | TOP2A 3693/4885ADORA1 32/4885TDO2 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.