Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PMM2 | O15305 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 2/20 | 0.34 |
| ▸ | MPI | P34949 | 2/20 | 0.34 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3109998 | 0.95 | GPR139 (0.35) | PDE5AGPR139GAAMEN1KMT2A | |
| SCHEMBL3758608 | 0.86 | MAPT (0.36) | PDE5AGPR139GAACASP1ALDH1A1 | |
| SCHEMBL3755762 | 0.81 | MAPT (0.36) | PDE5AGPR139GAAMEN1KMT2A | |
| SCHEMBL3119298 | 0.78 | KMT2A (0.36) | GPR139GAAMEN1KMT2ATRPA1 | |
| SCHEMBL3108716 | 0.78 | TRPA1 (0.37) | GPR139GAAMEN1KMT2ATRPA1 | |
| SCHEMBL3762536 | 0.77 | GPR139 (0.36) | GPR139GAAMEN1KMT2ACASP1 | |
| SCHEMBL3760928 | 0.77 | GPR139 (0.36) | GPR139GAAMEN1KMT2ACASP1 | |
| SCHEMBL3115203 | 0.71 | PLA2G2A (0.39) | GPR139MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3752413 | 0.71 | NFE2L2 (0.53) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3107703 | 0.71 | CASP1 (0.46) | PDE5ACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130029942-A1 | COMPOUNDS AND THERAPEUTICAL USES THEREOF | MYREXIS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8309562-B2 | Compounds and therapeutical use thereof | MYREXIS, INC. (US) | 2012-11-13 | — | — | US | disclosed |
| US-20100069383-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | Myriad Pharmaceuticals, Incorporated (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029942-A1 | COMPOUNDS AND THERAPEUTICAL USES THEREOF | BAD, CASP3, BAX | PDE5A 2924/4885GPR139 3975/4885GAA 194/4885 |
| US-20100069383-A1 | COMPOUNDS AND THERAPEUTICAL USE THEREOF | BAD, CASP3, BAX | PDE5A 3000/4885GPR139 3421/4885GAA 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.