Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9614829 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL7828749 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| Hydrochloric Acid SCHEMBL17597735 | 0.79 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| Hydrochloric Acid SCHEMBL17595031 | 0.79 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL1396731 | 0.73 | MAPK1 (0.58) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL22234491 | 0.73 | PTGS2 (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL3334681 | 0.73 | IRAK4 (0.46) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL3112903 | 0.73 | — | — | |
| Trifluoroacetic Acid SCHEMBL17595022 | 0.72 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL22497977 | 0.72 | TYK2 (0.45) | KDM4EALDH1A1SMN1; SMN2PARP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100279986-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-04 | — | — | US | disclosed |
| US-7803793-B2 | Heterocyclic derived metalloprotease inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| EP-2089365-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2009-08-19 | — | — | EP | disclosed |
| US-20080103129-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-01 | — | — | US | disclosed |
| WO-2008045668-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-17 | — | — | WO | disclosed |
| EP-0397409-B1 | THE STABILIZATION OF ORGANIC COMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 1993-07-21 | — | — | EP | disclosed |
| US-5185319-A | STABILIZATION OF ORGANIC COMPOUNDS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1993-02-09 | — | — | US | disclosed |
| EP-0397409-A1 | The stabilization of organic compounds | BTG INTERNATIONAL LIMITED (GB) | 1990-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103129-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | ADAM17, MMP25, ADAM33 | KDM4E 1117/4885ALDH1A1 530/4885SMN1; SMN2 1626/4885 |
| US-20100279986-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | ADAM17, MMP25, ADAM33 | KDM4E 1117/4885ALDH1A1 530/4885SMN1; SMN2 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.