Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31128598 | 0.87 | NOTUM (0.46) | RXFP1THRBKDM1ALRRK2GRM5 | |
| SCHEMBL31128534 | 0.74 | S1PR1 (0.38) | S1PR1BACE1KDM4EMAPTTDP1 | |
| SCHEMBL31128516 | 0.74 | THRB (0.56) | RXFP1THRBLMNAMAPT | |
| SCHEMBL31128602 | 0.73 | AR (0.44) | S1PR1KDM4EMAPTTDP1PGR | |
| SCHEMBL31128494 | 0.73 | KDM4E (0.39) | RXFP1THRBKDM4ELMNAMAPT | |
| SCHEMBL202404 | 0.69 | ALDH1A1 (0.61) | KDM1AGRM5PGR | |
| SCHEMBL509576 | 0.67 | ALDH1A1 (0.58) | KDM1AGRM5PGR | |
| SCHEMBL31128616 | 0.67 | S1PR1 (0.40) | S1PR1KDM4EMAPTTDP1 | |
| SCHEMBL10373598 | 0.66 | — | — | |
| SCHEMBL20282676 | 0.66 | ALDH1A1 (0.46) | KDM1ALRRK2GRM5HRH3PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173343-A1 | COMPOUNDS TARGETING HYDROXYSTEROID 17-BETA DEHYDROGENASE (HSD17B) AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2024-08-22 | — | — | WO | disclosed |