Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.58 |
| ▸ | ABAT | P80404 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | KDM4B | O94953 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.49 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16958859 | 0.85 | TSHR (0.60) | VCAM1TSHRMAPK1ALDH5A1ABAT | |
| SCHEMBL560001 | 0.85 | VCAM1 (1.00) | VCAM1MAPK1ALDH5A1ABATALDH1A1 | |
| SCHEMBL14564665 | 0.83 | TSHR (0.58) | VCAM1TSHRMAPK1ALDH5A1ABAT | |
| SCHEMBL16954832 | 0.83 | MAPK1 (0.58) | VCAM1TSHRMAPK1ALDH5A1ABAT | |
| SCHEMBL31484716 | 0.82 | ALDH5A1 (0.69) | VCAM1TSHRALDH5A1ABATALDH1A1 | |
| SCHEMBL1466944 | 0.82 | ALDH5A1 (0.69) | VCAM1TSHRALDH5A1ABATALDH1A1 | |
| SCHEMBL28519167 | 0.80 | FBP1 (0.58) | VCAM1TSHRMAPK1KDM4AKDM4B | |
| SCHEMBL28519165 | 0.80 | FBP1 (0.58) | VCAM1TSHRMAPK1KDM4AKDM4B | |
| SCHEMBL12492068 | 0.79 | MAPK1 (0.53) | VCAM1TSHRMAPK1ALDH1A1KDM4A | |
| SCHEMBL12492067 | 0.79 | MAPK1 (0.53) | VCAM1TSHRMAPK1ALDH1A1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4585265-A2 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024255765-A1 | NOVEL COMPOUNDS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | NUPHASE THERAPEUTICS (HANGZHOU) LIMITED., CO. (CN) | 2024-12-19 | — | — | WO | disclosed |
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| CN-116903469-A | Synthesis method of 4-nitrobenzophenone compound | 台州学院 | 2023-10-20 | — | — | CN | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| US-9371319-B2 | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-21 | — | — | US | disclosed |
| EP-2686318-B1 | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS | CANCER REC TECH LTD (GB) | 2016-03-09 | — | — | EP | disclosed |
| WO-2009002916-A2 | PROCESSES FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-31 | — | — | WO | disclosed |
| US-20070027143-A1 | Novel substituted 2,3-benzodiazepine derivatives | IVAX DRUG RESEARCH INSTITUTE, LTD. (HU) | 2007-02-01 | — | — | US | disclosed |
| CN-1747938-A | Novel substituted 2, 3-benzodiazepine * derivatives | IVAX INST FOR DRUG RES LTD (HU) | 2006-03-15 | — | — | CN | disclosed |
| US-4962146-A | 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives | SCHERING CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| US-4945021-A | ELECTROGRAPHY; DISPERSIBILITY, POT LIFE; PHOTOSENSITIVITY DURABILITY | MINOLTA CAMERA KABUSHIKI KAISHA (JP) | 1990-07-31 | — | — | US | disclosed |
| EP-0362267-A1 | 3-O-GLYCOSYL 16-MEMBERED MACROLIDE ANTIBACTERIALS AND RELATED DERIVATIVES | SCHERING CORPORATION (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4808575-A | BACTERICIDES, ANTIBIOTIC | SCHERING CORPORATION (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0290203-A1 | 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives | SCHERING CORPORATION (US) | 1988-11-09 | — | — | EP | disclosed |
| WO-1988008426-A1 | 3-O-GLYCOSYL 16-MEMBERED MACROLIDE ANTIBACTERIALS AND RELATED DERIVATIVES | SCHERING CORPORATION (US) | 1988-11-03 | — | — | WO | disclosed |
| US-4205193-A | CATALYST FROM ALUMINUM AND TITANIUM COMPOUND, ORGANOOXYGEN COMPOUND AND ORGANOSULFUR CONTAINING COMPOUND | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1980-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | VCAM1 577/4885TSHR 4000/4885MAPK1 3772/4885 |
| US-20070027143-A1 | Novel substituted 2,3-benzodiazepine derivatives | GABRB2, GABRB3, GABRA2 | VCAM1 1711/4885TSHR 2291/4885MAPK1 1879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.