Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 16/20 | 0.55 |
| ▸ | CTSS | P25774 | 9/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112612 | 0.82 | CTSK (0.50) | CTSKCTSSKCNH2CTSLCTSB | |
| SCHEMBL3106495 | 0.81 | CTSK (0.59) | CTSKCTSSKCNH2CTSLCTSB | |
| SCHEMBL27762078 | 0.76 | LMNA (0.43) | CTSKCTSSCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4444344 | 0.71 | CTSK (1.00) | CTSKCTSSKCNH2CTSLCTSB | |
| SCHEMBL3118138 | 0.70 | CTSS (0.61) | CTSKCTSS | |
| SCHEMBL3114437 | 0.70 | CTSK (0.52) | CTSKCTSSKCNH2CTSLCTSB | |
| SCHEMBL3108861 | 0.69 | PGK1 (0.41) | CTSS | |
| SCHEMBL4970801 | 0.68 | CTSS (0.33) | CTSS | |
| SCHEMBL3122345 | 0.68 | CTSK (1.00) | CTSKCTSSKCNH2CTSLCTSB | |
| SCHEMBL3114160 | 0.68 | CTSK (0.52) | CTSKCTSSKCNH2CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101374838-B | 6-phenyl-1h-imidazo[4,5-c]pyridine-4-carbonitrile derivatives as cathepsin K and S inhibitors | ORGANON NV | 2013-04-03 | — | — | CN | disclosed |
| EP-1979351-B1 | 6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS | ORGANON NV (NL) | 2010-04-07 | — | — | EP | disclosed |
| US-7687515-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2010-03-30 | — | — | US | disclosed |
| CN-101374838-A | 6-phenyl-1h-imidazo[4,5-c]pyridine-4-carbonitrile derivatives as cathepsin k and s inhibitors | ORGANON NV (NL) | 2009-02-25 | — | — | CN | disclosed |
| EP-1979351-A1 | 6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS | N.V. Organon (NL) | 2008-10-15 | — | — | EP | disclosed |
| US-20070179138-A1 | 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2007-08-02 | — | — | US | disclosed |
| WO-2007080191-A1 | 6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS | N.V. ORGANON (NL) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179138-A1 | 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | CTSK, CTSS, CTSZ | CTSK 1/4885CTSS 2/4885KCNH2 1786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.