Sugi Predict

Sugi Predict / Compounds / SCHEMBL3115309

SCHEMBL3115309

SCHEMBL3115309

Brc1ccc2c(c1)CCS2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSL P07711 1/20 0.42
▸ PNMT P11086 2/20 0.38
▸ ASIC3 Q9UHC3 1/20 0.38
▸ METAP1 P53582 1/20 0.36
▸ PARP10 Q53GL7 2/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ VHL P40337 1/20 0.35
▸ ELOC Q15369 1/20 0.35
▸ ELOB Q15370 1/20 0.35
▸ PARP11 Q9NR21 1/20 0.35
▸ SRD5A1 P18405 1/20 0.34
▸ SRD5A2 P31213 1/20 0.34
▸ KDM1A O60341 1/20 0.34
▸ SLC6A4 P31645 2/20 0.34
▸ KCNH2 Q12809 1/20 0.32
▸ RYR2 Q92736 1/20 0.32
▸ TDP2 O95551 1/20 0.32
▸ ADRA2A P08913 1/20 0.32
▸ ADRA2B P18089 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5198318 0.88 CTSL (0.37) CTSLPNMTASIC3METAP1PARP10
SCHEMBL9148423 0.86 CTSL (0.36) CTSLPNMTASIC3METAP1PARP10
SCHEMBL25569806 0.83 TDP1 (0.39) CTSLPNMTASIC3METAP1PARP10
SCHEMBL2796180 0.75 CTSL (0.38) CTSLMETAP1TDP1L3MBTL1VHL
SCHEMBL468939 0.74 CTSL (0.42) CTSLMETAP1PARP10VHLELOC
SCHEMBL18899426 0.74 ADRA2A (0.38) PNMTVHLELOCELOBSLC6A4
SCHEMBL14155100 0.74 CTSL (0.42) CTSLL3MBTL1VHLELOCELOB
SCHEMBL3924933 0.74 CASP1 (0.39) TDP1L3MBTL1VHLELOCELOB
SCHEMBL5422777 0.74 DRD2 (0.39) VHLELOCELOBSLC6A4
SCHEMBL11180283 0.74 VHL (0.56) CTSLPNMTMETAP1VHLELOC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008760-A1 DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF INSMED INCORPORATED 2026-01-08 — — US disclosed
US-20260001886-A1 ENPP1 INHIBITORS I RE VENTURES I LLC (US) 2026-01-01 — — US disclosed
EP-4665730-A1 HETEROCYCLIC GLP-1 AGONISTS Gasherbrum Bio, Inc. (US) 2025-12-24 — — EP disclosed
WO-2025233863-A1 ENPP1 INHIBITORS RE VENTURES I, LLC (US) 2025-11-13 — — WO disclosed
US-12291529-B2 Heterocyclic GLP-1 agonists GASHERBRUM BIO, INC. (US) 2025-05-06 — — US disclosed
WO-2024255765-A1 NOVEL COMPOUNDS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF NUPHASE THERAPEUTICS (HANGZHOU) LIMITED., CO. (CN) 2024-12-19 — — WO disclosed
CN-119019428-A Sulfinimides class compound and application thereof 中国药科大学 2024-11-26 — — CN disclosed
US-20240376105-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. 2024-11-14 — — US disclosed
US-20240327404-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO INC (US) 2024-10-03 — — US disclosed
WO-2024169952-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. (US) 2024-08-22 — — WO disclosed
EP-1530470-B9 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP LILLY CO ELI (US) 2010-04-07 — — EP disclosed
US-7585977-B2 Selective estrogen receptor modulators containing a phenylsulfonyl group ELI LILLY AND COMPANY (US) 2009-09-08 — — US disclosed
EP-1530470-B1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP LILLY CO ELI (US) 2009-06-10 — — EP disclosed
US-20080214612-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP DALLY ROBERT DEAN 2008-09-04 — — US disclosed
US-7399867-B2 Selective estrogen receptor modulators containing a phenylsulfonyl group ELI LILLY AND COMPANY (US) 2008-07-15 — — US disclosed
EP-1782810-A2 Selective estrogen receptor modulators containing a phenylsulfonyl group Eli Lilly & Company (US) 2007-05-09 — — EP disclosed
US-20060183736-A1 Selective estrogen receptor modulators containing a phenylsulfonyl group ELILILLY AND COMPANY 2006-08-17 — — US disclosed
EP-1530470-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP ELI LILLY AND COMPANY (US) 2005-05-18 — — EP disclosed
WO-2004009086-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP ELI LILLY AND COMPANY (US) 2004-01-29 — — WO disclosed
EP-1031572-A1 PYRIDYLPYRROLE DERIVATIVES Sankyo Company Limited (JP) 2000-08-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240376105-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, IAPP CTSL 2703/4885PNMT 3268/4885ASIC3 763/4885
US-20260001886-A1 ENPP1 INHIBITORS I ENPP1, ENPP2, ENPP3 CTSL 3581/4885PNMT 3866/4885ASIC3 3986/4885
US-20260008760-A1 DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF DPP9, DPP7, DPP4 CTSL 270/4885PNMT 4542/4885ASIC3 1426/4885
US-20080214612-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP GPER1, ESR2, ESR1 CTSL 4051/4885PNMT 2177/4885ASIC3 1126/4885
US-20060183736-A1 Selective estrogen receptor modulators containing a phenylsulfonyl group GPER1, ESR2, ESR1 CTSL 4051/4885PNMT 2177/4885ASIC3 1126/4885
US-12291529-B2 Heterocyclic GLP-1 agonists GLP1R, GIPR, IAPP CTSL 2703/4885PNMT 3268/4885ASIC3 763/4885
US-20240327404-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, IAPP CTSL 2703/4885PNMT 3268/4885ASIC3 763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.