Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128934 | 0.82 | RIPK1 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2HTR1A | |
| SCHEMBL3116258 | 0.81 | IDO1 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2HTR1A | |
| SCHEMBL3124006 | 0.79 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2HTR1A | |
| SCHEMBL3122107 | 0.79 | IDO1 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2HTR1A | |
| SCHEMBL3126134 | 0.78 | EPHX2 (0.33) | EPHX2 | |
| SCHEMBL3126431 | 0.76 | HTR1A (0.37) | SLC6A4HTR1A | |
| SCHEMBL3118087 | 0.76 | SIGMAR1 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL22283619 | 0.74 | MMP1 (0.33) | SLC6A2SLC6A4SLC6A3KCNH2EPHX2 | |
| SCHEMBL22283623 | 0.74 | MMP1 (0.33) | SLC6A2SLC6A4SLC6A3KCNH2EPHX2 | |
| SCHEMBL2299321 | 0.73 | DRD4 (0.50) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |