Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118087 | 0.84 | SIGMAR1 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2CARM1 | |
| SCHEMBL3126964 | 0.83 | CARM1 (0.55) | IDO1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3116276 | 0.81 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3KCNH2FAAH | |
| SCHEMBL19921484 | 0.79 | SLC6A2 (0.56) | IDO1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL12078032 | 0.79 | IDO1 (0.42) | IDO1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL2299321 | 0.78 | DRD4 (0.50) | SLC6A2SLC6A4SLC6A3KCNH2DRD4 | |
| SCHEMBL3128934 | 0.77 | RIPK1 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2CARM1 | |
| SCHEMBL2300380 | 0.74 | OPRM1 (0.51) | IDO1SLC6A2SLC6A4SLC6A3CARM1 | |
| SCHEMBL3126431 | 0.74 | HTR1A (0.37) | SLC6A4CARM1PRMT6DRD4HTR2A | |
| SCHEMBL31381241 | 0.73 | DGAT1 (0.43) | IDO1SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |