Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184643 | 1.00 | PARP1 (0.37) | PARP1MAPTHSD11B1GRM4CNR1 | |
| SCHEMBL31185021 | 0.93 | MAPT (0.36) | PARP1MAPTCNR1CNR2POLB | |
| SCHEMBL31184579 | 0.91 | ALDH1A1 (0.42) | MAPTPOLBLMNASMN1; SMN2MEN1 | |
| SCHEMBL31184982 | 0.89 | ALDH1A1 (0.42) | PARP1MAPTPOLBCRHBPCRHR2 | |
| SCHEMBL31184672 | 0.88 | MAPT (0.36) | PARP1MAPTGRM4CNR1CNR2 | |
| SCHEMBL31184778 | 0.87 | MAPT (0.40) | PARP1MAPTHSD11B1GRM4CNR1 | |
| SCHEMBL31184406 | 0.86 | POLB (0.43) | MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL31184478 | 0.82 | MAPT (0.38) | MAPTCNR1CNR2POLBCRHBP | |
| SCHEMBL31184884 | 0.80 | POLB (0.43) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL31184736 | 0.80 | CDK5 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220626-A1 | SMALL MOLECULE MODULATORS OF OGG1 | AZKARRA THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |