Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 4/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31203098 | 0.77 | LMNA (0.44) | LMNASMN1; SMN2MAPTCHEK1 | |
| SCHEMBL31203143 | 0.77 | NOS3 (0.41) | TGFBR1ACVR1SCN1ASCN8ALRRK2 | |
| SCHEMBL13419604 | 0.76 | ALDH1A1 (0.46) | LMNASCDSMN1; SMN2MAPT | |
| SCHEMBL20758198 | 0.76 | MAPT (0.49) | SMN1; SMN2MAOAMAOBMAPT | |
| SCHEMBL16701364 | 0.72 | SIRT6 (0.42) | LMNASCDSMN1; SMN2MAPT | |
| SCHEMBL19172510 | 0.72 | SMN1; SMN2 (0.40) | LMNASCDLRRK2KDM4ESMN1; SMN2 | |
| SCHEMBL14634542 | 0.72 | GPR119 (0.48) | SCN1ASCN8A | |
| SCHEMBL14634541 | 0.72 | GPR119 (0.48) | SCN1ASCN8A | |
| SCHEMBL19764135 | 0.71 | MAPT (0.42) | LMNASCDLRRK2MAPT | |
| SCHEMBL19174875 | 0.71 | ALDH1A1 (0.54) | LMNASCDKDM4ESMN1; SMN2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4711366-A1 | PYRIMIDO MACROHETEROCYCLIC COMPOUND AS WEE1-YES DUAL-TARGET INHIBITOR AND USE THEREOF | Mindrank AI Ltd. (CN) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024230807-A1 | PYRIMIDO MACROHETEROCYCLIC COMPOUND AS WEE1-YES DUAL-TARGET INHIBITOR AND USE THEREOF | 杭州德睿智药科技有限公司 | 2024-11-14 | — | — | WO | disclosed |