Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552298 | 0.89 | ALDH1A1 (0.59) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL8996460 | 0.87 | ALDH1A1 (0.57) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| SCHEMBL8338812 | 0.78 | CYP2C9 (0.57) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| Tromethamine SCHEMBL7603877 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| SCHEMBL28276697 | 0.76 | HSPA5 (0.71) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| SCHEMBL10944546 | 0.75 | HSPA5 (0.64) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| SCHEMBL3678396 | 0.75 | ALDH1A1 (0.66) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| SCHEMBL42656 | 0.74 | ALDH1A1 (0.64) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| SCHEMBL3793958 | 0.73 | GAA (0.57) | ALDH1A1TSHRMAPK1LMNAMEN1 | |
| Tromethamine SCHEMBL5026344 | 0.72 | ALDH1A1 (0.41) | ALDH1A1TSHRMAPK1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774996-B1 | NOVEL HYPERBRANCHED POLYESTERS AND THEIR USE AS WAX INHIBITOR, AS POUR POINT DEPRESSANT, AS LUBRICANT OR IN LUBRICATING OILS | BASF SE (DE) | 2024-09-04 | — | — | EP | disclosed |
| US-11447713-B2 | Hyperbranched polyesters and their use as wax inhibitor, as pour point depressant, as lubricant or in lubricating oils | BASF SE (DE) | 2022-09-20 | — | — | US | disclosed |
| EP-3658653-B1 | LUBRICANT COMPOSITION CONTAINING COPOLYMERS OF POLYISOBUTYLENEMETHACRYLATE | BASF SE (DE) | 2022-08-24 | — | — | EP | disclosed |
| WO-2022038011-A1 | LUBRICATION BY VAPORIZING AND DEPOSITING AN LUBRICANT ADDITIVE ON A MECHANICAL DEVICE | BASF SE (DE) | 2022-02-24 | — | — | WO | disclosed |
| US-20210147759-A1 | LUBRICANT COMPOSITION CONTAINING COPOLYMERS OF POLYISOBUTYLENEMETHACRYLATE | BASF SE (DE) | 2021-05-20 | — | — | US | disclosed |
| US-10975325-B2 | Poly(meth)acrylate copolymers with branched C17 alkyl chains and their use in lubricant oil compositions | BASF SE (DE) | 2021-04-13 | — | — | US | disclosed |
| EP-3774996-A1 | NOVEL HYPERBRANCHED POLYESTERS AND THEIR USE AS WAX INHIBITOR, AS POUR POINT DEPRESSANT, AS LUBRICANT OR IN LUBRICATING OILS | BASF SE (DE) | 2021-02-17 | — | — | EP | disclosed |
| EP-3774997-A1 | HYPERBRANCHED POLYETHERS AND THEIR USE, ESPECIALLY AS POUR POINT DEPRESSANT AND WAX INHIBITORS | BASF SE (DE) | 2021-02-17 | — | — | EP | disclosed |
| US-20210017466-A1 | NOVEL HYPERBRANCHED POLYESTERS AND THEIR USE AS WAX INHIBITOR, AS POUR POINT DEPRESSANT, AS LUBRICANT OR IN LUBRICATING OILS | BASF SE (DE) | 2021-01-21 | — | — | US | disclosed |
| US-20210017341-A1 | HYPERBRANCHED POLYETHERS AND THEIR USE, ESPECIALLY AS POUR POINT DEPRESSANT AND WAX INHIBITORS | BASF SE (DE) | 2021-01-21 | — | — | US | disclosed |
| WO-2008055797-A1 | METHACRYLATE COPOLYMER POURPOINT DEPRESSANTS | CIBA HOLDING INC. (CH) | 2008-05-15 | — | — | WO | disclosed |
| US-20080108533-A1 | Methacrylate copolymer pour point depressants | CIBA CORP. | 2008-05-08 | — | — | US | disclosed |
| US-20050006627-A1 | Sterically hindered phenol antioxidant granules having balanced hardness | ALBEMARLE CORPORATION | 2005-01-13 | — | — | US | disclosed |
| US-6750184-B2 | WITH DIPHENYLAMINES AND ZINC DITHIOPHOSPHATES; SUPERIOR ANTIOXIDATIVE PROPERTIES; RESISTS SLUDGE FORMATION | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-20020065201-A1 | Lubricants with 5-tert.-butyl-4-hydroxy-3-methylphenyl substituted fatty acid esters | CIBA SPECIALTY CHEMICALS CORP. | 2002-05-30 | — | — | US | disclosed |
| US-6353044-B1 | PHOTOSTABILITY OF POLYMER WITH BETA-(2,2,6,6-TETRAMETHYL PIPERIDINE-4-AMINO)ETHYL CROTONATE | GREAT LAKES CHEMICAL ITALIA S.R.L. (IT) | 2002-03-05 | — | — | US | disclosed |
| EP-1155098-A1 | LIQUID CRYSTALLINE SUBSTANCE MIXTURES | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-21 | — | — | EP | disclosed |
| EP-1110999-A2 | Stabilizing mixtures for organic polymers | Great Lakes Chemical (Europe) GmbH (CH) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000047694-A1 | LIQUID CRYSTALLINE SUBSTANCE MIXTURES | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-17 | — | — | WO | disclosed |
| US-6060543-A | STABILIZE ORGANIC MATERIAL AGAINST DAMAGE BY LIGHT, OXYGEN AND/OR HEAT | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-05-09 | — | — | US | disclosed |