Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194073 | 0.89 | ALDH1A1 (0.53) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| Tromethamine SCHEMBL5026344 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| Tromethamine SCHEMBL3124288 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| SCHEMBL9517658 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| SCHEMBL27600786 | 0.72 | CYP2C19 (0.46) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| SCHEMBL460071 | 0.68 | POLB (0.34) | ALDH1A1CYP2C19POLBHMGCR | |
| SCHEMBL8816811 | 0.68 | GABRA1 (0.37) | ALDH1A1CYP2C19POLBHMGCR | |
| SCHEMBL6474809 | 0.68 | ALDH1A1 (0.53) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| SCHEMBL16421746 | 0.68 | ALDH1A1 (0.53) | ALDH1A1TSHRKMT2AMAPK1LMNA | |
| SCHEMBL6273840 | 0.67 | ALDH1A1 (0.49) | ALDH1A1TSHRKMT2AMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111485325-A | High-temperature-resistant antibacterial nanofiber non-woven fabric and preparation method and application thereof | 青岛科技大学 | 2020-08-04 | — | — | CN | claimed |
| CN-110383164-B | Inhibitors of photo-thermally induced polymerization for electrophoretic media | 伊英克加利福尼亚有限责任公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-110551339-B | Polypropylene resin particles, polypropylene resin expanded particles, process for producing the same, and molded article | 钟化(苏州)缓冲材料有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-111485325-A | High-temperature-resistant antibacterial nanofiber non-woven fabric and preparation method and application thereof | 青岛科技大学 | 2020-08-04 | — | — | CN | disclosed |
| CN-111363251-A | Special coloring master batch for PPR pipe and preparation method and application thereof | 广东波斯科技股份有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-110551339-A | Polypropylene resin particles, polypropylene resin expanded particles, process for producing the same, and molded article | KANEKA EPERAN SUZHOU CO LTD | 2019-12-10 | — | — | CN | disclosed |
| US-6451888-B1 | Solid stabilizer composition with improved hydrolytic stability | GENERAL ELECTRIC COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-4540538-A | POLYOXYALKYLENE GLYCOL ANTIGEL AND INORGANIC AGENT FOR REMOVAL OF RESIDUAL CHLORIDE | UNION CARBIDE CORPORATION (US) | 1985-09-10 | — | — | US | disclosed |