SCHEMBL3125425

SCHEMBL3125425

O=C(O)c1c2nc(cc3ccc(cc4nc(cc5ccc1[nH]5)C=C4)[nH]3)C=C2

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.49
▸ STAT1 P42224 1/20 0.49
▸ TOP1 P11387 3/20 0.36
▸ CYCS P99999 3/20 0.35
▸ SMAD3 P84022 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5034725 0.95 STAT3 (0.47) STAT3STAT1TOP1CYCSSMAD3
SCHEMBL8909390 0.89 STAT3 (0.42) STAT3STAT1TOP1CYCSSMAD3
SCHEMBL351897 0.87 STAT3 (0.45) STAT3STAT1TOP1
SCHEMBL6094135 0.87 STAT3 (0.45) STAT3STAT1TOP1
SCHEMBL16673442 0.86 STAT3 (0.44) STAT3STAT1
SCHEMBL455573 0.85 STAT3 (0.67) STAT3STAT1TOP1CYCS
SCHEMBL4270473 0.85 STAT3 (0.43) STAT3STAT1
SCHEMBL8977875 0.84 STAT3 (0.69) STAT3STAT1TOP1CYCS
SCHEMBL1596068 0.84 STAT3 (0.47) STAT3STAT1TOP1CYCS
SCHEMBL6413587 0.83 ABCG2 (0.43) STAT3STAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113318707-B Organic supermolecule gel system of binuclear rhodium-porphyrin derivative and preparation method thereof 曲阜师范大学 2022-09-16 — — CN claimed
CN-113583011-A Water-soluble porphyrin carboxylate and preparation method and application thereof 安徽清科瑞洁新材料有限公司 2021-11-02 — — CN claimed
CN-113318707-A Organic supermolecule gel system of binuclear rhodium-porphyrin derivative and preparation method thereof 曲阜师范大学 2021-08-31 — — CN claimed
CN-110982084-B Zirconium metal organic framework material based on shortest porphyrin carboxylic acid ligand, preparation and application thereof 北京工业大学 2021-05-14 — — CN claimed
CN-110982084-A Zirconium metal organic framework material based on shortest porphyrin carboxylic acid ligand, preparation and application thereof 北京工业大学 2020-04-10 — — CN claimed
CN-110354901-A A kind of preparation method and application of the monatomic porphyryl MOF material of metal 重庆工商大学 2019-10-22 — — CN claimed
CN-119039304-A Carboxyl porphyrin-curcumin esterified conjugate and preparation method and application thereof 中南大学 2024-11-29 — — CN disclosed
CN-117186764-B Polydopamine/porphyrin coating and preparation method thereof 南昌师范学院 2024-03-29 — — CN disclosed
CN-117186764-A Polydopamine/porphyrin coating and preparation method thereof 南昌师范学院 2023-12-08 — — CN disclosed
CN-116920810-A Porphyrin-based porous adsorbent and application thereof in adsorption removal of perfluoroalkyl compound in water 河北工业大学 2023-10-24 — — CN disclosed
US-20230302144-A1 Porphyrin Compounds and Compositions Useful for Treating Cancer ONCOSELECT THERAPEUTICS, LLC (US) 2023-09-28 — — US disclosed
CN-114854033-B Preparation and application of Eu metal-organic framework material based on non-planar porphyrin ligand 北京工业大学 2023-09-01 — — CN disclosed
US-11590233-B2 Porphyrin compounds and compositions useful for treating cancer ONCOSELECT THERAPEUTICS, LLC (US) 2023-02-28 — — US disclosed
EP-0723548-A4 PHOSPHORESCENT COMPOUNDS FOR IMAGING TISSUE OXYGEN UNIV PENNSYLVANIA (US) 1997-01-15 — — EP disclosed
EP-0723548-A1 PHOSPHORESCENT COMPOUNDS FOR IMAGING TISSUE OXYGEN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1996-07-31 — — EP disclosed
WO-1995010522-A1 PHOSPHORESCENT COMPOUNDS FOR IMAGING TISSUE OXYGEN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1995-04-20 — — WO disclosed
US-5387719-A Preparation of aldehydes BASF AKTIENGESELLSCHAFT (DE) 1995-02-07 — — US disclosed
EP-0118913-B1 PORPHYRIN DERIVATIVES Shudo, Koichi, Prof. Dr. (JP) 1989-06-21 — — EP disclosed
US-4658023-A ANTITUMOR AGENTS SHUDO KOICHI (JP) 1987-04-14 — — US disclosed
EP-0118913-A2 Porphyrin derivatives Shudo, Koichi, Prof. Dr. (JP) 1984-09-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230302144-A1 Porphyrin Compounds and Compositions Useful for Treating Cancer KIT, HCCS, PPIF STAT3 1427/4885STAT1 4192/4885TOP1 176/4885
US-11590233-B2 Porphyrin compounds and compositions useful for treating cancer KIT, HCCS, PPIF STAT3 1427/4885STAT1 4192/4885TOP1 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback