SCHEMBL5034725

SCHEMBL5034725

O=C(O)c1c2nc(c(C(=O)O)c3ccc(cc4nc(cc5ccc1[nH]5)C=C4)[nH]3)C=C2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.47
▸ STAT1 P42224 1/20 0.47
▸ TOP1 P11387 3/20 0.40
▸ CYCS P99999 3/20 0.39
▸ ABCG2 Q9UNQ0 1/20 0.32
▸ SMAD3 P84022 1/20 0.31
▸ F7 P08709 1/20 0.30
▸ F3 P13726 1/20 0.30
▸ PIN1 Q13526 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ PDPK1 O15530 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ LMNA P02545 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ TSHR P16473 1/20 0.30
▸ NFKB1 P19838 1/20 0.30
▸ APEX1 P27695 1/20 0.30
▸ CYP2C19 P33261 1/20 0.30
▸ HSD17B10 Q99714 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3125425 0.95 STAT3 (0.49) STAT3STAT1TOP1CYCSSMAD3
SCHEMBL8909390 0.93 STAT3 (0.42) STAT3STAT1TOP1CYCSSMAD3
SCHEMBL455573 0.89 STAT3 (0.67) STAT3STAT1TOP1CYCSABCG2
SCHEMBL351526 0.87 STAT3 (0.43) STAT3STAT1TOP1CYCSABCG2
SCHEMBL6092415 0.87 STAT3 (0.43) STAT3STAT1TOP1CYCSABCG2
SCHEMBL8977875 0.85 STAT3 (0.69) STAT3STAT1TOP1CYCSABCG2
SCHEMBL10523389 0.85 STAT3 (0.36) STAT3STAT1TOP1CYCS
SCHEMBL6014909 0.84 STAT3 (0.36) STAT3STAT1TOP1
SCHEMBL351897 0.82 STAT3 (0.45) STAT3STAT1TOP1ABCG2HSD17B10
SCHEMBL6094135 0.82 STAT3 (0.45) STAT3STAT1TOP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3611033-B1 TIRE, AND METHOD FOR MANUFACTURING TIRE BRIDGESTONE CORP (JP) 2022-05-04 — — EP disclosed
EP-3266623-B1 TIRE BRIDGESTONE CORP (JP) 2022-02-09 — — EP disclosed
US-20200061979-A1 TIRE, AND METHOD FOR MANUFACTURING TIRE BRIDGESTONE CORPORATION (JP) 2020-02-27 — — US disclosed
EP-3611033-A1 TIRE, AND METHOD FOR MANUFACTURING TIRE Bridgestone Corporation (JP) 2020-02-19 — — EP disclosed
EP-3513989-A1 TIRE Bridgestone Corporation (JP) 2019-07-24 — — EP disclosed
US-20190202239-A1 TIRE BRIDGESTONE CORPORATION (JP) 2019-07-04 — — US disclosed
EP-3199571-B1 TIRE BRIDGESTONE CORP (JP) 2019-06-05 — — EP disclosed
US-20180050565-A1 TIRE BRIDGESTONE CORPORATION (JP) 2018-02-22 — — US disclosed
EP-3266623-A1 TIRE Bridgestone Corporation (JP) 2018-01-10 — — EP disclosed
US-20170298182-A1 TIRE BRIDGESTONE CORPORATION (JP) 2017-10-19 — — US disclosed
EP-3199571-A1 TIRE Bridgestone Corporation (JP) 2017-08-02 — — EP disclosed
US-20080283122-A1 Beta-Substituted Porphyrins CAMPBELL WAYNE MASON 2008-11-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080283122-A1 Beta-Substituted Porphyrins PPOX, HMBS, CRY1 STAT3 3336/4885STAT1 4389/4885TOP1 2190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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