Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11277959 | 0.90 | NPC1 (0.46) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL3130089 | 0.86 | NPC1 (0.53) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL7129964 | 0.84 | ALOX5 (0.66) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL3130096 | 0.82 | ALDH1A1 (0.54) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL3750325 | 0.82 | POLB (0.59) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL8504937 | 0.82 | KMT2A (0.68) | NPC1RAB9ALMNAALOX5MAPK1 | |
| SCHEMBL5146521 | 0.82 | LMNA (0.55) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL27929137 | 0.81 | NPC1 (0.52) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL5460753 | 0.81 | ALDH1A1 (0.54) | NPC1RAB9ALMNAALOX5TSHR | |
| SCHEMBL3125806 | 0.81 | NPC1 (0.52) | NPC1RAB9ALMNAALOX5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141148-B1 | INDOLE DERIVATIVE HAVING CPLA2 INHIBITORY ACTIVITY, USE OF THE SAME AND METHOD FOR PRODUCING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2013-07-03 | — | — | EP | disclosed |
| US-8293781-B2 | Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-10-23 | — | — | US | disclosed |
| US-20100113777-A1 | INDOLE DERIVATIVES HAVING cPLA2 INHIBITING ACTIVITY AND APPLICATIONS AND PRODUCTION METHODS OF THE SAME | ASUBIO PHARMA CO., LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
| EP-2141148-A1 | INDOLE DERIVATIVE HAVING CPLA2 INHIBITORY ACTIVITY, USE OF THE SAME AND METHOD FOR PRODUCING THE SAME | Asubio Pharma Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113777-A1 | INDOLE DERIVATIVES HAVING cPLA2 INHIBITING ACTIVITY AND APPLICATIONS AND PRODUCTION METHODS OF THE SAME | PLA2G4A, PLA2G2E, PLA2G6 | NPC1 1359/4885RAB9A 3763/4885LMNA 1862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.