SCHEMBL3126492

SCHEMBL3126492

COc1ccc(/C=C2/C(=O)C(C)(C)OC2(C)C)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 6/20 0.50
CLK1 P49759 5/20 0.50
GSK3B P49841 1/20 0.50
DYRK1B Q9Y463 5/20 0.48
MAPT P10636 1/20 0.48
METAP1 P53582 1/20 0.47
PIM1 P11309 1/20 0.46
AKR1B1 P15121 1/20 0.46
PIM2 Q9P1W9 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
CSNK2A2 P19784 2/20 0.45
CSNK2B P67870 2/20 0.45
CSNK2A1 P68400 2/20 0.45
DYRK2 Q92630 1/20 0.45
CYP1A2 P05177 1/20 0.44
ALDH1A1 P00352 2/20 0.43
CYP2A6 P11509 1/20 0.43
POLB P06746 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3126497 1.00 DYRK1A (0.50) DYRK1ACLK1GSK3BDYRK1BMAPT
SCHEMBL13299569 0.88 LMNA (0.50) DYRK1ACLK1GSK3BMAPTMETAP1
SCHEMBL9463137 0.88 LMNA (0.50) DYRK1ACLK1GSK3BMAPTMETAP1
SCHEMBL9463193 0.80 LMNA (0.58) MAPTPIM1PIM2CYP1A2ALDH1A1
SCHEMBL9488911 0.78 NR5A1 (0.47) MAPTPIM1PIM2ALDH1A1LMNA
SCHEMBL9463169 0.76 METAP1 (0.46) MAPTMETAP1PIM1CSNK2A2CSNK2B
SCHEMBL9472495 0.75 METAP1 (0.49) DYRK1ACLK1GSK3BDYRK1BMAPT
SCHEMBL28494165 0.73 DYRK1A (0.57) DYRK1ACLK1GSK3BDYRK1BMAPT
SCHEMBL3076077 0.70 KMT2A (0.65) DYRK1ACLK1GSK3BDYRK1BMAPT
SCHEMBL28117370 0.70 METAP1 (0.46) DYRK1ACLK1GSK3BDYRK1BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 US claimed
EP-1370232-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2003-12-17 EP claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 US claimed
EP-1317918-A1 Cosmetic sunscreen compositions based on synergistic filter mixture and their use L'OREAL (FR) 2003-06-11 EP claimed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 WO claimed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 WO claimed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 EP disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 US disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 US disclosed
CN-107847414-B Composition comprising a UV screening agent, an anionically crosslinked hydrophilic polymer, a surfactant having an HLB less than or equal to 5, and a siloxane copolymer 欧莱雅 2021-09-10 CN disclosed
EP-3185843-B1 GEL COMPOSITION AND GEL COMPRISING A UV FILTER OREAL (FR) 2021-08-11 EP disclosed
EP-3185843-B1 GEL COMPOSITION AND GEL COMPRISING A UV FILTER OREAL (FR) 2021-08-11 EP disclosed
EP-1317918-A1 Cosmetic sunscreen compositions based on synergistic filter mixture and their use L'OREAL (FR) 2003-06-11 EP disclosed
EP-1302197-A1 Use of amphiphilic copolymers to stabilise dispersions of non-soluble organic compounds filtering UV light L'OREAL (FR) 2003-04-16 EP disclosed
US-20030053966-A1 Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof L'OREAL (FR) 2003-03-20 US disclosed
EP-1281391-A1 Organic insoluble UV filters of the aryl vinylene ketone type and their use in cosmetics L'OREAL (FR) 2003-02-05 EP disclosed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 WO disclosed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD DYRK1A 1733/4885CLK1 3779/4885GSK3B 2485/4885
US-20030053966-A1 Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof PRKDC, AHR, TYR DYRK1A 2484/4885CLK1 2055/4885GSK3B 4315/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 DYRK1A 3053/4885CLK1 937/4885GSK3B 4194/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 DYRK1A 2459/4885CLK1 3658/4885GSK3B 2290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.