Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL134068 | 0.85 | ALDH1A1 (0.60) | CA1CA2CA9CA12PTGS2 | |
| SCHEMBL11051151 | 0.80 | PTGS2 (0.46) | CA1CA2CA9CA12PTGS2 | |
| Sulfuric Acid SCHEMBL7040609 | 0.80 | CA2 (0.54) | CA1CA2CA9CA12PTGS2 | |
| Biphenyl SCHEMBL21462355 | 0.80 | ALDH1A1 (0.53) | CA1CA2CA9CA12PTGS2 | |
| Biphenyl SCHEMBL27509992 | 0.80 | CA2 (0.61) | CA1CA2CA9CA12PTGS2 | |
| SCHEMBL8770202 | 0.79 | PTGS2 (0.79) | CA1CA2CA9CA12PTGS2 | |
| SCHEMBL1687503 | 0.79 | PTGS2 (0.79) | CA1CA2CA9CA12PTGS2 | |
| SCHEMBL18342129 | 0.79 | ALDH1A1 (0.65) | CA1CA2CA9CA12PTGS2 | |
| Biphenyl SCHEMBL10325169 | 0.78 | CA2 (0.65) | CA1CA2CA9CA12PTGS2 | |
| SCHEMBL27483186 | 0.78 | ALDH1A1 (0.50) | CA1CA2CA9CA12PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115175681-B | Use of sGC activators for the treatment of ophthalmic diseases | 拜耳公司 | 2024-10-25 | — | — | CN | disclosed |