Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31320125 | 0.87 | ABL1 (0.44) | ABL1JAK2JAK1TYK2PIK3CA | |
| SCHEMBL31320122 | 0.78 | TYK2 (0.43) | TYK2IDO1 | |
| SCHEMBL31320136 | 0.77 | GAA (0.51) | ABL1 | |
| SCHEMBL31320126 | 0.76 | AURKA (0.49) | — | |
| SCHEMBL31320119 | 0.73 | MAPK1 (0.37) | ABL1MAPK1 | |
| SCHEMBL31320118 | 0.70 | ABL1 (0.41) | ABL1JAK2JAK1TYK2PIK3CA | |
| SCHEMBL31320133 | 0.69 | GRM4 (0.34) | ABL1MAPK1 | |
| SCHEMBL23694234 | 0.69 | MEN1 (0.38) | MAPK1 | |
| SCHEMBL31032965 | 0.69 | KDR (0.41) | ABL1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12410296 | 0.69 | ABL1 (0.54) | ABL1MKNK2FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024240108-A1 | ARYL UREA PARP1 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海海和药物研究开发股份有限公司 | 2024-11-28 | — | — | WO | disclosed |