Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.62 |
| ▸ | DHODH | Q02127 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033752 | 0.85 | HDAC6 (0.73) | PLAUHDAC8HDAC6HDAC2PLK1 | |
| SCHEMBL12571872 | 0.81 | OGG1 (0.66) | PLAUDHODHHTTSMN1; SMN2SIRT1 | |
| SCHEMBL6640227 | 0.81 | PLAU (0.66) | PLAUHDAC8HDAC6HDAC2PLK1 | |
| SCHEMBL761366 | 0.81 | PLAU (0.66) | PLAUHDAC8HDAC6HDAC2PLK1 | |
| SCHEMBL30369626 | 0.81 | PLAU (0.66) | PLAUHDAC8HDAC6HDAC2PLK1 | |
| SCHEMBL31069565 | 0.81 | PLAU (0.51) | PLAUDHODHHDAC8HDAC6HDAC2 | |
| SCHEMBL1737861 | 0.81 | ALDH1A1 (0.52) | PLAUDHODHHPGDHTTSIRT1 | |
| SCHEMBL1736411 | 0.81 | CYP3A4 (0.53) | PLAUDHODHHDAC8HDAC6HDAC2 | |
| SCHEMBL1665292 | 0.80 | HDAC2 (0.71) | HDAC8HDAC6HDAC2PLK1HPGD | |
| SCHEMBL5431020 | 0.80 | PLAU (0.55) | PLAUDHODHSIRT1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115436500-A | Method for identifying operable cut DNA coding seedling head compound | 成都先导药物开发股份有限公司 | 2022-12-06 | — | — | CN | claimed |
| CN-115436500-A | Method for identifying operable cut DNA coding seedling head compound | 成都先导药物开发股份有限公司 | 2022-12-06 | — | — | CN | disclosed |
| US-10005780-B2 | Production method of imidazole derivatives | TAKEDA PHARMACEUTICAL COMPANY (JP) | 2018-06-26 | — | — | US | disclosed |
| US-20160244454-A1 | PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES | TAKEDA PHARMACEUTICALS CO (JP) | 2016-08-25 | — | — | US | disclosed |
| US-9278938-B2 | Production method of imidazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-03-08 | — | — | US | disclosed |
| CN-103608334-B | The preparation method of imdazole derivatives | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-12-23 | — | — | CN | disclosed |
| EP-2721010-B1 | PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2015-09-09 | — | — | EP | disclosed |
| US-8828429-B2 | Release-control composition | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-09-09 | — | — | US | disclosed |
| EP-2721010-A1 | PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-20140100373-A1 | PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-10 | — | — | US | disclosed |
| EP-1681290-A2 | Imidazole derivatives, production method thereof and use thereof | Takeda Pharmaceutical Company Limited (JP) | 2006-07-19 | — | — | EP | disclosed |
| EP-1334106-B1 | IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2006-05-24 | — | — | EP | disclosed |
| CN-1680336-A | New imidazole derivative, method for producing the same and use of the same | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-10-12 | — | — | CN | disclosed |
| CN-1639130-A | Process for preparing fused imidazole compounds, rifumassiy reagent in stable form and process for preparing same | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-07-13 | — | — | CN | disclosed |
| US-20050043544-A1 | Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-02-24 | — | — | US | disclosed |
| EP-1471056-A1 | PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-20040033935-A1 | Novel imidazole derivatives, production method thereof and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-02-19 | — | — | US | disclosed |
| CN-1474819-A | Novel imidazole derivatives, process for producing the same and use thereof | ����ҩƷ��ҵ��ʽ���� | 2004-02-11 | — | — | CN | disclosed |
| EP-1334106-A2 | NOVEL IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002040484-A2 | NOVEL IMIDAZOLE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244454-A1 | PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES | GRIK4, PPIP5K2, IP6K2 | PLAU 3925/4885DHODH 1788/4885HDAC8 244/4885 |
| US-10005780-B2 | Production method of imidazole derivatives | GRIK4, PPIP5K2, IP6K2 | PLAU 3925/4885DHODH 1788/4885HDAC8 244/4885 |
| US-20040033935-A1 | Novel imidazole derivatives, production method thereof and use thereof | CYP17A1, CYP21A2, CYP19A1 | PLAU 630/4885DHODH 148/4885HDAC8 885/4885 |
| US-20140100373-A1 | PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES | GRIK4, PPIP5K2, IP6K2 | PLAU 3925/4885DHODH 1788/4885HDAC8 244/4885 |
| US-20050043544-A1 | Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same | CYP17A1, HSD17B7, HSD17B1 | PLAU 3952/4885DHODH 132/4885HDAC8 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.