SCHEMBL31333486

SCHEMBL31333486

CC(C)(C)OC(=O)[C@H]1CC[C@H](CN2CCN(c3ccc(N)cc3F)CC2)CC1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.46
MAPT P10636 5/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
MAPK1 P28482 1/20 0.41
GFER P55789 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
GAA P10253 1/20 0.39
ACHE P22303 1/20 0.39
HTR4 Q13639 1/20 0.39
DRD3 P35462 1/20 0.37
SLC6A9 P48067 2/20 0.36
NR1H2 P55055 1/20 0.36
GPR55 Q9Y2T6 1/20 0.36
HRH1 P35367 1/20 0.36
CCR3 P51677 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334725 0.92 ACHE (0.43) DRD2MAPTALDH1A1LMNAMAPK1
SCHEMBL31333198 0.88 DRD2 (0.43) DRD2MAPTALDH1A1LMNAMAPK1
SCHEMBL25172818 0.86 MAPT (0.46) MAPTALDH1A1LMNAMAPK1GFER
SCHEMBL27162423 0.86 GPR119 (0.46) ALDH1A1NR1H2
SCHEMBL31334895 0.85 DRD2 (0.62) DRD2
SCHEMBL27225248 0.85 DRD2 (0.62) DRD2DRD3
SCHEMBL31333749 0.85 GPR119 (0.41) DRD2ACHEHTR4NR1H2HRH1
SCHEMBL31333288 0.84 MAPT (0.43) DRD2MAPTALDH1A1LMNAMAPK1
SCHEMBL21786071 0.84 CNR1 (0.44) MAPTALDH1A1MAPK1NR1H2
SCHEMBL157877 0.83 MAPT (0.56) MAPTALDH1A1LMNAMAPK1GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed