Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CASP1 | P29466 | 3/20 | 1.00 |
| ▸ | CASP7 | P55210 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | XDH | P47989 | 2/20 | 0.72 |
| ▸ | DPP4 | P27487 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | IPMK | Q8NFU5 | 2/20 | 0.65 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31412250 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL1250547 | 0.91 | XDH (0.86) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL2629300 | 0.90 | ABCG2 (1.00) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL26936149 | 0.89 | KDM4E (0.82) | KDM4ECYP3A4MAPTLMNACASP1 | |
| Pentamethylquercetin SCHEMBL16292202 | 0.88 | KDM4E (0.77) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL748580 | 0.88 | ABCG2 (0.86) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL4147950 | 0.87 | ABCG2 (0.81) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL2629309 | 0.86 | ABCG2 (0.84) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL14011591 | 0.86 | ABCG2 (0.77) | KDM4ECYP3A4MAPTLMNACASP1 | |
| SCHEMBL38650680 | 0.86 | ABCG2 (0.83) | KDM4ECYP3A4MAPTLMNACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683095-B2 | Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2010-03-23 | — | — | US | claimed |
| WO-2006132879-A2 | SOFT GEL CAPSULES CONTAINING POLYMETHOXYLATED FLAVONES AND PALM OIL TOCOTRIENOLS | SOFT GEL TECHNOLOGIES, INC. (US) | 2006-12-14 | — | — | WO | claimed |
| US-6987125-B1 | Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2006-01-17 | — | — | US | claimed |
| US-20060003947-A1 | Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols | THE CIT GROUP/CREDIT FINANCE, INC. | 2006-01-05 | — | — | US | claimed |
| US-20050249803-A1 | Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols | SOFT GEL TECHNOLOGIES, INC. | 2005-11-10 | — | — | US | claimed |
| EP-1278417-A1 | COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES | KGK Synergie (CA) | 2003-01-29 | — | — | EP | claimed |
| WO-2001070029-A1 | COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES | KGK SYNERGIE (CA) | 2001-09-27 | — | — | WO | claimed |
| US-20250011722-A1 | HEPATIC ORGANOIDS | KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) | 2025-01-09 | — | — | US | disclosed |
| WO-2023085931-A1 | HEPATIC ORGANOIDS | KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) | 2023-05-19 | — | — | WO | disclosed |
| CN-110818553-B | Anti-inflammatory compound of desmodium parvifolium and preparation method thereof | 青海师范大学 | 2022-06-14 | — | — | CN | disclosed |
| US-20220125766-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAGGIES PEARL LLC (US) | 2022-04-28 | — | — | US | disclosed |
| US-20220125766-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAGGIES PEARL LLC (US) | 2022-04-28 | — | — | US | disclosed |
| US-11160794-B2 | Methods for treating congenital disorders of glycosylation | MAGGIE'S PEARL, LLC (US) | 2021-11-02 | — | — | US | disclosed |
| US-20040214882-A1 | Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones | INTERHEALTH NUTRACEUTICALS INCORPORATED | 2004-10-28 | — | — | US | disclosed |
| US-20040097493-A1 | For preparing medicaments useful for the therapy of the p38 MAP kinase and FGFR kinase mediated diseases and conditions | HOFFMANN-LA ROCHE INC. | 2004-05-20 | — | — | US | disclosed |
| EP-1278417-A1 | COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES | KGK Synergie (CA) | 2003-01-29 | — | — | EP | disclosed |
| EP-1119353-A4 | COMPOSITIONS AND METHODS OF INHIBITING NEOPLASTIC DISEASES WITH COMPOUNDS RELATED TO LIMOCITRIN AND 5-DESMETHYL SINENSETIN | KGK SYNERGIZE INC (CA) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001070029-A1 | COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES | KGK SYNERGIE (CA) | 2001-09-27 | — | — | WO | disclosed |
| EP-1119353-A1 | COMPOSITIONS AND METHODS OF INHIBITING NEOPLASTIC DISEASES WITH COMPOUNDS RELATED TO LIMOCITRIN AND 5-DESMETHYL SINENSETIN | KGK Synergize Inc. (CA) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000019998-A1 | COMPOSITIONS AND METHODS OF INHIBITING NEOPLASTIC DISEASES WITH COMPOUNDS RELATED TO LIMOCITRIN AND 5-DESMETHYL SINENSETIN | KGK SYNERGIZE (CA) | 2000-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050249803-A1 | Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols | TTPA, CCNE2, PTGES | KDM4E 1084/4885CYP3A4 1187/4885MAPT 1749/4885 |
| US-11160794-B2 | Methods for treating congenital disorders of glycosylation | MAN1B1, MAN2B1, GAA | KDM4E 3915/4885CYP3A4 4252/4885MAPT 3244/4885 |
| US-20060003947-A1 | Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols | TTPA, PLA2G10, GSTO1 | KDM4E 652/4885CYP3A4 890/4885MAPT 3282/4885 |
| US-20220125766-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAN1B1, MAN2B1, GAA | KDM4E 3915/4885CYP3A4 4252/4885MAPT 3244/4885 |
| US-20040097493-A1 | For preparing medicaments useful for the therapy of the p38 MAP kinase and FGFR kinase mediated diseases and conditions | FGFR1, MAPK1, FGF1 | KDM4E 4627/4885CYP3A4 4702/4885MAPT 1042/4885 |
| US-20040214882-A1 | Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones | TNNT2, PLIN3, TNNI3 | KDM4E 2659/4885CYP3A4 926/4885MAPT 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.