Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | THRA | P10827 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130687 | 0.77 | HDAC1 (0.37) | HDAC1HDAC8THRATHRBNTRK1 | |
| SCHEMBL3142272 | 0.73 | THRA (0.36) | THRATHRBMEN1LMNAKMT2A | |
| SCHEMBL3137471 | 0.72 | THRB (0.53) | THRATHRBMEN1KMT2AHDAC6 | |
| SCHEMBL3141802 | 0.71 | MAPT (0.38) | THRATHRBMEN1LMNAKMT2A | |
| SCHEMBL4529355 | 0.70 | MEN1 (0.36) | HDAC1HDAC8THRATHRBMEN1 | |
| SCHEMBL4529353 | 0.70 | MEN1 (0.34) | HDAC1HDAC8THRATHRBMEN1 | |
| SCHEMBL11876883 | 0.68 | MEN1 (0.43) | MEN1LMNAKMT2APARG | |
| SCHEMBL3129784 | 0.61 | THRB (0.46) | THRATHRBMEN1KMT2A | |
| SCHEMBL3979678 | 0.60 | THRA (0.56) | THRATHRBMEN1LMNAKMT2A | |
| SCHEMBL11874680 | 0.60 | ALDH1A1 (0.41) | HDAC1HDAC8THRBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | HDAC1 264/4885HDAC8 683/4885THRA 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.