Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 5/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.31 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2958374 | 0.79 | SIRT1 (0.37) | ICMTP2RX7CA2PLA2G2AACLY | |
| SCHEMBL24410529 | 0.79 | MEP1B (0.36) | P2RX7ACLYMEP1BGAA | |
| SCHEMBL13235168 | 0.76 | GABRA1 (0.37) | — | |
| SCHEMBL4468444 | 0.75 | — | — | |
| SCHEMBL17802717 | 0.75 | GAA (0.38) | ICMTCA2MEP1BGAANPSR1 | |
| SCHEMBL21996264 | 0.73 | DGAT1 (0.47) | CA2KIF11GAA | |
| SCHEMBL2564601 | 0.72 | CES2 (0.43) | ICMTP2RX7CA2GAANPSR1 | |
| SCHEMBL2151373 | 0.72 | CES2 (0.43) | ICMTP2RX7CA2GAANPSR1 | |
| SCHEMBL17330382 | 0.71 | SIRT1 (0.49) | SIRT1 | |
| SCHEMBL15524379 | 0.71 | ICMT (0.43) | ICMTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513050-B | Heterocyclic compounds which inhibit SHP2 activity | 大鹏药品工业株式会社 | 2024-12-20 | — | — | CN | disclosed |