SCHEMBL3139853

SCHEMBL3139853

O=S(=O)(O)c1ccc(C(F)(F)F)cc1.Sc1cccc(-c2ccc(Cl)cc2)c1-c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.44
TP53 P04637 1/20 0.44
EDNRB P24530 1/20 0.42
EDNRA P25101 1/20 0.42
KLRK1 P26718 1/20 0.40
MICA Q29983 1/20 0.40
RAET1L Q5VY80 1/20 0.40
PTGS2 P35354 2/20 0.40
PTGS1 P23219 1/20 0.40
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
CNR2 P34972 1/20 0.39
KDM1A O60341 2/20 0.38
ENPP3 O14638 1/20 0.38
ENPP1 P22413 1/20 0.38
ENPP2 Q13822 1/20 0.38
KIF11 P52732 1/20 0.38
MMP2 P08253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3139786 0.94 MEN1 (0.43) MAPTEDNRBEDNRAPTGS2PTGS1
SCHEMBL3130395 0.89 HSD11B1 (0.44) MAPTPTGS2PTGS1MEN1LMNA
SCHEMBL3132857 0.89 KIF11 (0.44) MAPTPTGS2PTGS1MEN1LMNA
SCHEMBL3143584 0.88 ALDH1A1 (0.42) MAPTPTGS2PTGS1MEN1LMNA
SCHEMBL3132925 0.88 ALDH1A1 (0.42) MAPTPTGS2PTGS1MEN1LMNA
SCHEMBL3134809 0.88 MMP2 (0.40) MAPTTP53PTGS2MEN1LMNA
SCHEMBL3136311 0.85 PTGS2 (0.44) MAPTTP53PTGS2PTGS1LMNA
SCHEMBL3143278 0.85 TP53 (0.47) TP53PTGS2PTGS1ENPP1PTGDR2
Trifluoromethanesulfonic Acid SCHEMBL1089067 0.84 PTGS2 (0.39) MAPTTP53EDNRBEDNRAKLRK1
Trifluoromethanesulfonic Acid SCHEMBL3134866 0.83 MAPT (0.39) MAPTTP53MEN1LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1676835-B1 PROCESS FOR PRODUCING TRIARYLSULFONIUM SALT WAKO PURE CHEM IND LTD (JP) 2014-12-10 EP disclosed
US-7642368-B2 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2010-01-05 US disclosed
US-20070083060-A1 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) 2007-04-12 US disclosed
EP-1676835-A1 PROCESS FOR PRODUCING TRIARYLSULFONIUM SALT Wako Pure Chemical Industries, Ltd. (JP) 2006-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070083060-A1 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid ARSA, HAO2, HAO1 MAPT 4793/4885TP53 4084/4885EDNRB 3759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.