SCHEMBL31409141

SCHEMBL31409141

COc1ccc(N2C(=O)c3ccccc3CC2c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.55
RAB9A P51151 3/20 0.54
NPC1 O15118 2/20 0.54
PKM P14618 1/20 0.54
ABAT P80404 1/20 0.52
ABCB1 P08183 2/20 0.50
GFER P55789 1/20 0.50
HSD11B1 P28845 1/20 0.49
KDM4E B2RXH2 1/20 0.47
TSHR P16473 1/20 0.47
MAPT P10636 1/20 0.47
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
STING1 Q86WV6 1/20 0.44
DRD3 P35462 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31409167 0.95 RAB9A (0.51) ALDH1A1RAB9ANPC1PKMABAT
SCHEMBL31409136 0.86 RAB9A (0.47) RAB9ANPC1PKMKDM4EMEN1
SCHEMBL15841547 0.81 GFER (0.60) ALDH1A1ABATGFERHSD11B1TSHR
SCHEMBL15841548 0.81 GFER (0.60) ALDH1A1ABATGFERHSD11B1TSHR
SCHEMBL8782404 0.80 NPC1 (0.51) ALDH1A1RAB9ANPC1PKMTSHR
SCHEMBL31409122 0.78 KMT2A (0.53) ALDH1A1RAB9ANPC1PKMHSD11B1
SCHEMBL31409139 0.77 HSD11B1 (0.49) ALDH1A1RAB9ANPC1HSD11B1KDM4E
SCHEMBL29975007 0.75 L3MBTL1 (0.56) ALDH1A1ABATGFERHSD11B1KDM4E
SCHEMBL1997854 0.75 L3MBTL1 (0.56) ALDH1A1ABATGFERHSD11B1KDM4E
SCHEMBL31409153 0.74 GFER (0.50) ALDH1A1RAB9ANPC1GFERKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119506909-A Method for electrochemically synthesizing 3, 4-dihydro-isoquinoline-1 (2H) -ketone compound 宜宾学院 2025-02-25 CN disclosed