Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | PYGM | P11217 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28757734 | 0.87 | CACNA1B (0.50) | POLBALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL27463118 | 0.85 | LMNA (0.48) | POLBALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL4086461 | 0.82 | ADRB2 (0.41) | POLBALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3145712 | 0.81 | SIGMAR1 (0.44) | — | |
| SCHEMBL3131545 | 0.79 | CCR5 (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4096230 | 0.79 | TPSAB1 (0.43) | ALDH1A1TSHR | |
| SCHEMBL3255015 | 0.79 | SIGMAR1 (0.42) | — | |
| SCHEMBL8414762 | 0.78 | RAB9A (0.42) | POLBALDH1A1LMNACYP51A1GPR183 | |
| SCHEMBL3136133 | 0.78 | CA12 (0.38) | ALDH1A1TSHR | |
| SCHEMBL3137377 | 0.78 | TPSAB1 (0.43) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636224-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE | PROSIDION LTD (GB) | 2010-07-14 | — | — | EP | disclosed |
| CN-100480249-C | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2009-04-22 | — | — | CN | disclosed |
| CN-1826340-A | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2006-08-30 | — | — | CN | disclosed |
| US-5952322-A | AMIDE-SUBSTITUTED BENZIMIDAZOLE, INDOLE DERIVATIVES | PFIZER INC. (US) | 1999-09-14 | — | — | US | disclosed |
| CN-1142492-A | Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |