Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.41 |
| ▸ | ACP1 | P24666 | 2/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.38 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.38 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MMP10 | P09238 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484826 | 0.86 | GRIA4 (0.56) | CA1CA2GRIA4ACP1TACR1 | |
| SCHEMBL3147764 | 0.79 | CA1 (0.58) | CA1CA2GRIA4ALDH1A1MMP7 | |
| SCHEMBL5222475 | 0.76 | TAAR1 (0.46) | CA1CA2TACR1ALDH1A1MAPT | |
| SCHEMBL4478694 | 0.76 | TACR1 (0.44) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL4478411 | 0.76 | TACR1 (0.44) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL5412263 | 0.75 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL2802418 | 0.75 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL5395813 | 0.75 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL2181410 | 0.75 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL20530516 | 0.72 | MAPT (0.41) | CA1CA2ACP1PTPN7PTPN12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294630-B2 | Piperazinyl piperidine tachykinin antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-13 | — | — | US | claimed |
| US-20060142302-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | claimed |
| EP-1921064-B1 | Pharmaceutical composition | GLAXO GROUP LTD (GB) | 2010-05-19 | — | — | EP | disclosed |
| US-20100081667-A1 | Chemical Compounds | ALVARO GIUSEPPE | 2010-04-01 | — | — | US | disclosed |
| US-7648990-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2010-01-19 | — | — | US | disclosed |
| EP-1921064-A1 | Pharmaceutical composition | GLAXO GROUP LIMITED (GB) | 2008-05-14 | — | — | EP | disclosed |
| US-20080021041-A1 | Chemical Compounds | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | US | disclosed |
| US-7294630-B2 | Piperazinyl piperidine tachykinin antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-13 | — | — | US | disclosed |
| EP-1524266-B1 | Pharmaceutical composition | GLAXO GROUP LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1752449-A1 | Pharmaceutical coposition | GLAXO GROUP LIMITED (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-7119092-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060142302-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| US-7060702-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050137208-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2005-06-23 | — | — | US | disclosed |
| EP-1524266-A1 | Pharmaceutical composition | GLAXO GROUP LIMITED (GB) | 2005-04-20 | — | — | EP | disclosed |
| EP-1326832-B1 | CHEMICAL COMPOUNDS | GLAXO GROUP LTD (GB) | 2004-10-06 | — | — | EP | disclosed |
| US-20040014770-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | US | disclosed |
| EP-1326832-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032867-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021041-A1 | Chemical Compounds | OPRL1, OPRK1, OPRM1 | CA1 139/4885CA2 369/4885GRIA4 485/4885 |
| US-20050137208-A1 | Chemical compounds | TACR2, TAC3, MC2R | CA1 450/4885CA2 172/4885GRIA4 526/4885 |
| US-20040014770-A1 | Chemical compounds | HCK, KCNK4, GRK4 | CA1 956/4885CA2 533/4885GRIA4 652/4885 |
| US-20060142302-A1 | Chemical compounds | TACR2, TAC3, MC2R | CA1 450/4885CA2 172/4885GRIA4 526/4885 |
| US-20100081667-A1 | Chemical Compounds | OPRL1, OPRK1, OPRM1 | CA1 139/4885CA2 369/4885GRIA4 485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.