Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.58 |
| ▸ | CA2 | P00918 | 5/20 | 0.58 |
| ▸ | GBA1 | P04062 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484826 | 0.80 | GRIA4 (0.56) | CA1CA2ALDH1A1GRIA4 | |
| SCHEMBL3142706 | 0.79 | CA1 (0.43) | CA1CA2ALDH1A1GRIA4MMP7 | |
| SCHEMBL15621568 | 0.75 | CA1 (0.79) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL30800478 | 0.75 | CA2 (0.75) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL7862567 | 0.74 | GBA1 (0.74) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL30800477 | 0.74 | CA1 (1.00) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL29543465 | 0.73 | GBA1 (0.72) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL17206014 | 0.73 | GBA1 (0.67) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL23165092 | 0.73 | GBA1 (0.58) | CA1CA2GBA1ALDH1A1TSHR | |
| SCHEMBL6324136 | 0.73 | CA1 (0.75) | CA1CA2GBA1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294630-B2 | Piperazinyl piperidine tachykinin antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-13 | — | — | US | claimed |
| US-20060142302-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | claimed |
| EP-1921064-B1 | Pharmaceutical composition | GLAXO GROUP LTD (GB) | 2010-05-19 | — | — | EP | disclosed |
| US-20100081667-A1 | Chemical Compounds | ALVARO GIUSEPPE | 2010-04-01 | — | — | US | disclosed |
| US-7648990-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2010-01-19 | — | — | US | disclosed |
| EP-1921064-A1 | Pharmaceutical composition | GLAXO GROUP LIMITED (GB) | 2008-05-14 | — | — | EP | disclosed |
| US-20080021041-A1 | Chemical Compounds | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | US | disclosed |
| US-7294630-B2 | Piperazinyl piperidine tachykinin antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-13 | — | — | US | disclosed |
| EP-1524266-B1 | Pharmaceutical composition | GLAXO GROUP LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1752449-A1 | Pharmaceutical coposition | GLAXO GROUP LIMITED (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-7119092-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060142302-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| US-7060702-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050137208-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2005-06-23 | — | — | US | disclosed |
| EP-1524266-A1 | Pharmaceutical composition | GLAXO GROUP LIMITED (GB) | 2005-04-20 | — | — | EP | disclosed |
| EP-1326832-B1 | CHEMICAL COMPOUNDS | GLAXO GROUP LTD (GB) | 2004-10-06 | — | — | EP | disclosed |
| US-20040014770-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | US | disclosed |
| EP-1326832-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032867-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021041-A1 | Chemical Compounds | OPRL1, OPRK1, OPRM1 | CA1 139/4885CA2 369/4885GBA1 3032/4885 |
| US-20050137208-A1 | Chemical compounds | TACR2, TAC3, MC2R | CA1 450/4885CA2 172/4885GBA1 2995/4885 |
| US-20040014770-A1 | Chemical compounds | HCK, KCNK4, GRK4 | CA1 956/4885CA2 533/4885GBA1 2575/4885 |
| US-20060142302-A1 | Chemical compounds | TACR2, TAC3, MC2R | CA1 450/4885CA2 172/4885GBA1 2995/4885 |
| US-20100081667-A1 | Chemical Compounds | OPRL1, OPRK1, OPRM1 | CA1 139/4885CA2 369/4885GBA1 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.