Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143452 | 0.87 | ALDH1A1 (0.41) | FADS1ALDH1A1POLBGAAPARP1 | |
| SCHEMBL21772779 | 0.82 | FADS1 (0.40) | FADS1ALDH1A1POLBGAAPARP1 | |
| SCHEMBL3155115 | 0.77 | KDM4E (0.47) | ALDH1A1GAAKDM4EHTT | |
| SCHEMBL6101637 | 0.76 | ALDH1A1 (0.47) | ALDH1A1POLBGAASLC2A1MEN1 | |
| SCHEMBL22346510 | 0.74 | PABPC1 (0.39) | ALDH1A1POLBGAAPARP1SLC2A1 | |
| SCHEMBL23456478 | 0.72 | FADS1 (0.41) | FADS1ALDH1A1POLBGAAPARP1 | |
| SCHEMBL21772792 | 0.72 | ALDH1A1 (0.41) | FADS1ALDH1A1POLBGAAPARP1 | |
| SCHEMBL6101878 | 0.70 | PABPC1 (0.56) | ALDH1A1POLBGAASLC2A1MEN1 | |
| SCHEMBL3152080 | 0.69 | PKM (0.56) | ALDH1A1POLBGAAPKMKMT2A | |
| SCHEMBL6216870 | 0.69 | ADRA2A (0.52) | FADS1ALDH1A1POLBGAAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636225-B1 | PYRIDINO 1,2-A PYRIMIDIN-4-ONE COMPOUNDS AS ANTICANCER AGENTS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-1636225-B1 | PYRIDINO 1,2-A PYRIMIDIN-4-ONE COMPOUNDS AS ANTICANCER AGENTS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-02-24 | — | — | EP | disclosed |
| US-7326711-B2 | Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents | CHIRON CORPORATION (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326711-B2 | Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents | CHIRON CORPORATION (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326711-B2 | Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents | CHIRON CORPORATION (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1636225-A2 | PYRIDINO 1,2-A PYRIMIDIN-4-ONE COMPOUNDS AS ANTICANCER AGENTS | Chiron Corporation (US) | 2006-03-22 | — | — | EP | disclosed |
| US-20050085490-A1 | Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents | CHIRON CORPORATION | 2005-04-21 | — | — | US | disclosed |
| WO-2004113335-A2 | PYRIDINO[1,2-A]PYRIMIDIN-4-ONE COMPOUNDS AS ANTICANCER AGENTS | CHIRON CORPORATION (US) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085490-A1 | Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents | TYMP, DPYD, TK1 | FADS1 3303/4885ALDH1A1 290/4885POLB 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.