Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.35 |
| ▸ | PPARG | P37231 | 7/20 | 0.35 |
| ▸ | PPARD | Q03181 | 7/20 | 0.35 |
| ▸ | PPARA | Q07869 | 7/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22033474 | 0.76 | GPR84 (0.50) | CES1CES2ALDH1A1AKR1B1GPR84 | |
| SCHEMBL6059827 | 0.74 | ALDH1A1 (0.40) | CES1CES2ALDH1A1TP53TSHR | |
| SCHEMBL3176238 | 0.73 | CES2 (0.44) | CES1CES2ALDH1A1AKR1B1GPR84 | |
| SCHEMBL28471629 | 0.71 | CES1 (0.38) | CES1CES2ALDH1A1AKR1B1TP53 | |
| SCHEMBL8775440 | 0.70 | FFAR3 (0.42) | CES1CES2ALDH1A1AKR1B1GPR84 | |
| SCHEMBL7233038 | 0.69 | CES2 (0.48) | CES1CES2ALDH1A1GPR84PPARG | |
| SCHEMBL22033617 | 0.67 | FAAH (0.45) | CES1CES2ALDH1A1GPR84PPARG | |
| SCHEMBL29242032 | 0.67 | CES1 (0.42) | CES1CES2ALDH1A1AKR1B1TP53 | |
| SCHEMBL13190849 | 0.66 | CES1 (0.38) | CES1CES2ALDH1A1TSHR | |
| Valeric Acid SCHEMBL5047450 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8269024-B2 | Compounds and methods for modulating communication and virulence in quorum sensing bacteria | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100305182-A1 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA | BLACKWELL HELEN E | 2010-12-02 | — | — | US | disclosed |
| US-7642285-B2 | Compounds and methods for modulating communication and virulence in quorum sensing bacteria | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-01-05 | — | — | US | disclosed |
| EP-1848703-A2 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-10-31 | — | — | EP | disclosed |
| US-20060178430-A1 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-08-10 | — | — | US | disclosed |
| WO-2006084056-A2 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305182-A1 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA | AHCYL1, BPHL, AIP | CES1 3566/4885CES2 4012/4885ALDH1A1 4080/4885 |
| US-20060178430-A1 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA | AHCYL1, BPHL, AIP | CES1 3566/4885CES2 4012/4885ALDH1A1 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.