Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31455483 | 0.82 | DHFR (0.35) | MAPTALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL31455365 | 0.81 | MAPT (0.41) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL31455469 | 0.80 | MAPT (0.43) | MAPTTDP1NOS3NOS1NOS2 | |
| SCHEMBL31455344 | 0.77 | MAPT (0.43) | MAPTTDP1NOS3NOS1NOS2 | |
| SCHEMBL31455401 | 0.77 | MAPT (0.43) | MAPTTDP1NOS3NOS1NOS2 | |
| SCHEMBL31455425 | 0.72 | GSK3B (0.36) | MAPTALDH1A1HPGDMAPK1NPC1 | |
| SCHEMBL31455078 | 0.71 | ALDH1A1 (0.51) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL8949097 | 0.69 | ALDH1A1 (0.50) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL25928005 | 0.69 | ALDH1A1 (0.50) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1588195 | 0.67 | MAPT (0.42) | MAPTTDP1ALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025059577-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS FOR USE AS AKT1 INHIBITORS | ATAVISTIK BIO, INC. (US) | 2025-03-20 | — | — | WO | disclosed |