Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.50 |
| ▸ | PRCP | P42785 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | EBP | Q15125 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500303 | 0.85 | SIGMAR1 (0.68) | SIGMAR1KDM4EALDH1A1KCNH2KCNJ1 | |
| Hydrochloric Acid SCHEMBL14486498 | 0.84 | SIGMAR1 (0.66) | SIGMAR1KDM4EALDH1A1KCNH2KCNJ1 | |
| SCHEMBL10900445 | 0.80 | KCNH2 (0.57) | SIGMAR1KCNH2KCNJ1LMNASLC6A4 | |
| SCHEMBL5857488 | 0.77 | KCNH2 (0.57) | SIGMAR1KCNH2KCNJ1EBPSLC6A4 | |
| SCHEMBL10899595 | 0.77 | KCNH2 (0.57) | SIGMAR1ALDH1A1KCNH2KCNJ1SLC6A4 | |
| SCHEMBL9319743 | 0.76 | SIGMAR1 (0.70) | SIGMAR1KDM4EALDH1A1KCNH2KCNJ1 | |
| SCHEMBL9320154 | 0.75 | SIGMAR1 (0.63) | SIGMAR1KCNH2KCNJ1LMNASLC6A4 | |
| SCHEMBL5450696 | 0.75 | KCNH2 (0.55) | SIGMAR1KDM4EALDH1A1KCNH2KCNJ1 | |
| Trifluoroacetic Acid SCHEMBL22123107 | 0.75 | KDM4E (0.39) | SIGMAR1KDM4EALDH1A1LMNASLC2A1 | |
| Hydrochloric Acid SCHEMBL30152527 | 0.74 | KCNH2 (0.54) | SIGMAR1KDM4EALDH1A1KCNH2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234992-B1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2012-02-22 | — | — | EP | disclosed |
| US-8093248-B2 | Compounds useful for the treatment of conditions associated with weight gain | ASTRAZENECA AB (PUBL) (SE) | 2012-01-10 | — | — | US | disclosed |
| EP-2234992-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| US-20090281087-A1 | Compounds II | BIOVITRUM AB (SE) | 2009-11-12 | — | — | US | disclosed |
| WO-2009071668-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281087-A1 | Compounds II | GPR119, FABP4, LIPC | SIGMAR1 2023/4885KDM4E 3606/4885ALDH1A1 2717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.