Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB1 | P11230 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142735 | 0.87 | S1PR1 (0.38) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3150645 | 0.87 | CYP11B1 (0.47) | BACE1 | |
| SCHEMBL3147229 | 0.86 | CHRNB2 (0.49) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3137054 | 0.86 | CYP11B2 (0.39) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3147306 | 0.86 | INPPL1 (0.43) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3141660 | 0.86 | CYP11B1 (0.46) | BACE1 | |
| Hydrochloric Acid SCHEMBL3765553 | 0.85 | CHRNB2 (0.48) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3137112 | 0.83 | GABRG2 (0.44) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3772099 | 0.82 | GABRG2 (0.46) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3151845 | 0.81 | CHRNB2 (0.56) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |