Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | APP | P05067 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3781375 | 0.99 | ABL1 (0.34) | ABL1APPBACE1FYNMAPT | |
| SCHEMBL3143028 | 0.89 | CHRNB4 (0.39) | APPBACE1MAPT | |
| Hydrochloric Acid SCHEMBL3773920 | 0.88 | CHRNB4 (0.39) | APPBACE1MAPT | |
| SCHEMBL3144019 | 0.87 | FYN (0.37) | ABL1FYN | |
| Hydrochloric Acid SCHEMBL3774548 | 0.86 | PRKCZ (0.32) | APPNUDT1PRKCZFFAR4 | |
| SCHEMBL3138283 | 0.85 | CHRNB4 (0.40) | FFAR4 | |
| Hydrochloric Acid SCHEMBL3767949 | 0.84 | CHRNB4 (0.39) | FFAR4 | |
| SCHEMBL3147209 | 0.83 | ABL1 (0.39) | ABL1FFAR4 | |
| SCHEMBL3145347 | 0.81 | DHFR (0.37) | APPBACE1FYN | |
| Hydrochloric Acid SCHEMBL3773421 | 0.80 | DHFR (0.36) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |