Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5906656 | 0.79 | GABRP (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5353528 | 0.75 | MAPT (0.43) | ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL6319603 | 0.75 | ALDH1A1 (0.52) | NR4A3ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL5359650 | 0.73 | MAPT (0.41) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL7318932 | 0.73 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27788040 | 0.70 | L3MBTL1 (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24112327 | 0.70 | ALDH1A1 (0.34) | ALDH1A1KDM4EMAPTCYP2C19 | |
| SCHEMBL27815941 | 0.70 | PTGER1 (0.40) | ALDH1A1KDM4EMAPTPKMCYP2C19 | |
| SCHEMBL29199938 | 0.70 | ALKBH1 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4376014 | 0.69 | TSHR (0.45) | ALDH1A1KDM4EMAPTTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099452-B1 | TRICARBONYL COMPLEXES WITH TRIDENTATE CHELATORS FOR MYOCARDIUM IMAGING | MALLINCKRODT LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| US-9023315-B2 | Tricarbonyl complexes with tridentate chelators for myocardium imaging | MALLINCKRODT LLC (US) | 2015-05-05 | — | — | US | disclosed |
| US-8940273-B2 | Tricarbonyl complexes with tridentate chelators for myocardium imaging | MALLINCKRODT LLC (US) | 2015-01-27 | — | — | US | disclosed |
| US-20130131327-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | MALLINCKRODT LLC (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130129620-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | MALLINCKRODT LLC (US) | 2013-05-23 | — | — | US | disclosed |
| US-8372379-B2 | Technetium-99m (I) tricarbonyl complexes with tridentate chelators for myocardium imaging | MALLINCKRODT LLC (US) | 2013-02-12 | — | — | US | disclosed |
| US-20100074842-A1 | Technetium-99m (I) Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | LIEBEL-FLARSHEIM COMPANY LLC | 2010-03-25 | — | — | US | disclosed |
| EP-2099452-A2 | TRICARBONYL COMPLEXES WITH TRIDENTATE CHELATORS FOR MYOCARDIUM IMAGING | Mallinckrodt Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008061792-A2 | TRICARBONYL COMPLEXES WITH TRIDENTATE CHELATORS FOR MYOCARDIUM IMAGING | MALLINCKRODT INC. (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131327-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | TNNT2, TNNI3, FABP3 | GABRP 2926/4885GABRD 3052/4885GABRA1 3133/4885 |
| US-20100074842-A1 | Technetium-99m (I) Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | TNNT2, TNNI3, FABP3 | GABRP 2892/4885GABRD 3188/4885GABRA1 2991/4885 |
| US-20130129620-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | TNNT2, TNNI3, FABP3 | GABRP 2926/4885GABRD 3052/4885GABRA1 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.